	US 12,145,130 B2
	Multimodal adsorption medium with multimodal ligands, method for the preparation and use thereof
Lukas Kupracz, Hannover (DE); Florian Taft, Hannover (DE); Louis Villain, Hannover (DE); and Kornelia Kuper, Göttingen (DE)
Assigned to Sartorius Stedim Biotech GmbH, Göttingen (DE)
Filed by Sartorius Stedim Biotech GmbH, Göttingen (DE)
Filed on Sep. 2, 2021, as Appl. No. 17/465,052.
Application 17/465,052 is a continuation of application No. 16/092,353, abandoned, previously published as PCT/EP2017/000430, filed on Apr. 5, 2017.
Claims priority of application No. 10 2016 004 432.2 (DE), filed on Apr. 12, 2016.
Prior Publication US 2022/0055015 A1, Feb. 24, 2022
Int. Cl. B01D 15/38 (2006.01); B01J 20/24 (2006.01); B01J 20/26 (2006.01); B01J 20/288 (2006.01); B01J 20/289 (2006.01); B01J 20/32 (2006.01); C07K 1/16 (2006.01); C07K 16/00 (2006.01)

CPC B01J 20/288 (2013.01) [B01D 15/3847 (2013.01); B01J 20/24 (2013.01); B01J 20/261 (2013.01); B01J 20/265 (2013.01); B01J 20/289 (2013.01); B01J 20/3212 (2013.01); B01J 20/3219 (2013.01); B01J 20/3227 (2013.01); B01J 20/3248 (2013.01); B01J 20/3285 (2013.01); C07K 1/16 (2013.01); C07K 1/165 (2013.01); C07K 16/00 (2013.01); B01J 2220/52 (2013.01)]

6 Claims

1. A multimodal adsorption medium having a functional surface, comprising a polymeric carrier material with polymeric spacer elements bound to the surface thereof, to which multimodal ligands of the following structure -G-(CO₂H)_nare covalently bonded via an —X—(C═O) group,

where T denotes the polymeric carrier material with the polymeric spacer elements bound to the surface thereof,

X denotes an —NH— moiety on the polymeric spacer element,

the structure -G-(CO₂H)_nis selected from the group consisting of (3), (4), (6) to (14) and (15):

and

wherein the polymeric spacer elements are selected from the group consisting of polyallylamine, polyvinyladine, poly(4-aminostyrene), poly-L-lysine, poly(N-methylvinylamine), poly(N-methylallylamine) and poly(oleylamine).