US 12,144,967 B2
Medicament delivery device
Stefan Verlaak, Milan (IT); and Ilario Melzi, Milan (IT)
Assigned to Sanofi-Aventis Deutschland GMBH, Frankfurt am Main (DE)
Appl. No. 16/478,091
Filed by Sanofi-Aventis Deutschland GMBH, Frankfurt am Main (DE)
PCT Filed Jan. 22, 2018, PCT No. PCT/EP2018/051375
§ 371(c)(1), (2) Date Jul. 15, 2019,
PCT Pub. No. WO2018/138022, PCT Pub. Date Aug. 2, 2018.
Claims priority of application No. 17152921 (EP), filed on Jan. 24, 2017.
Prior Publication US 2019/0366002 A1, Dec. 5, 2019
Int. Cl. A61M 5/142 (2006.01); A61M 5/145 (2006.01); A61M 5/155 (2006.01); A61M 5/20 (2006.01)
CPC A61M 5/2046 (2013.01) [A61M 5/14248 (2013.01); A61M 5/14586 (2013.01); A61M 5/155 (2013.01); A61M 2205/587 (2013.01); A61M 2205/8225 (2013.01); A61M 2205/825 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A large volume device (LVD) configured to deliver a liquid medicament to a patient, the LVD comprising:
a housing configured to adhere to the patient's skin during the delivery of the liquid medicament to the patient, the housing containing:
a needle injection system configured to insert a needle into the patient at the housing;
a rigid casing containing a deformable medicament container that is configured to contain the liquid medicament in an initial state of the LVD;
a pressurized gas cartridge;
an overflow reservoir; and
a flow detection mechanism in the overflow reservoir,
wherein the deformable medicament container is in fluid communication with an outlet, and wherein the outlet is connected via a fluid path to the needle;
wherein the pressurized gas cartridge is connected to the rigid casing via a gas valve;
wherein the overflow reservoir is connected to the rigid casing via a safety valve, the safety valve having an open state and a closed state, and the overflow reservoir arranged to receive gas from the rigid casing when the safety valve is in the open state;
wherein the gas valve is releasable to allow a flow of the gas into the rigid casing to cause an increase in a pressure of the gas in the rigid casing so as to compress the deformable medicament container to displace the liquid medicament, and wherein the safety valve is configured to transition from the closed state to the open state to allow the flow of the gas from the rigid casing into the overflow reservoir when the pressure of the gas in the rigid casing exceeds a predetermined threshold corresponding to when an injection process is complete; and
wherein the flow detection mechanism comprises a rotation member arranged in the overflow reservoir that is configured to be rotated by the flow of the gas in the overflow reservoir to indicate when the injection process is complete, wherein the rotation member is connected to an indicator system comprising an indicator member, and wherein the rotation member is arranged to move the indicator member from a first position corresponding to a first state in which the injection process is not complete to a second position corresponding to a second state in which the injection process is complete.