US 12,144,965 B2
Automated system for regulating the blood glucose level of a patient
Romain Blanc, Grenoble (FR); Eléonore Maeva Doron, Grenoble (FR); and Emma Villeneuve, Grenoble (FR)
Assigned to Commissariat à l'Énergie Atomique et aux Énergies Alternatives, Paris (FR)
Appl. No. 17/414,901
Filed by Commissariat à l'Énergie Atomique et aux Énergies Alternatives, Paris (FR)
PCT Filed Dec. 20, 2019, PCT No. PCT/FR2019/053237
§ 371(c)(1), (2) Date Jun. 16, 2021,
PCT Pub. No. WO2020/128387, PCT Pub. Date Jun. 25, 2020.
Claims priority of application No. 1873812 (FR), filed on Dec. 21, 2018.
Prior Publication US 2022/0062551 A1, Mar. 3, 2022
Int. Cl. A61M 5/172 (2006.01); G16H 20/17 (2018.01); G16H 40/63 (2018.01); G16H 10/60 (2018.01)
CPC A61M 5/1723 (2013.01) [G16H 20/17 (2018.01); G16H 40/63 (2018.01); A61M 2205/18 (2013.01); A61M 2205/50 (2013.01); A61M 2230/201 (2013.01); A61M 2230/63 (2013.01); G16H 10/60 (2018.01)] 13 Claims
OG exemplary drawing
 
1. Automated system of regulation of a patient's blood glucose, comprising:
a blood glucose sensor;
an insulin injection device; and
a processing and control unit,
wherein the processing and control unit is configured to implement a hypoglycemia minimization method comprising the steps of:
a) detecting a possible hypoglycemia to come based on blood glucose measurements supplied by the blood glucose sensor;
b) determining a value BGdebt representative of a blood glucose debt to be compensated to avoid the hypoglycemia detected at step a) and a value Thypo representative of the time remaining before the beginning of the hypoglycemia detected at step a);
c) determining a value Tautosugaring representative of the duration necessary to enable the patient to compensate for the blood glucose debt BGdebt determined at step b) by endogenous glucose production;
d) comparing the value Tautosugaring determined at step c) with a value Thypo-TH, where TH is a predetermined time margin; and
e) when it is determined at step d) that value Tautosugaring is greater than or equal to value Thypo-TH, controlling the interruption of the insulin flow injected to the patient by the insulin injection device and/or starting an alert via a user interface device of the system to indicate to the patient that they must perform a carbohydrate ingestion.