US 12,144,945 B2
Balloon catheter systems for delivery of dry drug delivery vesicles to a vessel in the body
William R. Baumbach, New Hope, PA (US); Darren R. Sherman, New Hope, PA (US); and Robert S. Burgermeister, New Hope, PA (US)
Assigned to Caliber Therapeutics, LLC, New Hope, PA (US)
Filed by Caliber Therapeutics, LLC, New Hope, PA (US)
Filed on Feb. 15, 2023, as Appl. No. 18/110,041.
Application 14/247,057 is a division of application No. 13/855,653, filed on Apr. 2, 2013, granted, now 8,715,230, issued on May 6, 2014.
Application 18/110,041 is a continuation of application No. 17/075,080, filed on Oct. 20, 2020, abandoned.
Application 17/075,080 is a continuation of application No. 16/115,467, filed on Aug. 28, 2018, granted, now 10,806,909, issued on Oct. 20, 2020.
Application 16/115,467 is a continuation of application No. 15/594,055, filed on May 12, 2017, granted, now 10,207,084, issued on Feb. 19, 2019.
Application 15/594,055 is a continuation of application No. 15/078,940, filed on Mar. 23, 2016, granted, now 9,649,479, issued on May 16, 2017.
Application 15/078,940 is a continuation of application No. 14/247,057, filed on Apr. 7, 2014, granted, now 9,649,478, issued on May 16, 2017.
Application 14/247,057 is a continuation of application No. 12/982,760, filed on Dec. 30, 2010, granted, now 8,696,644, issued on Apr. 15, 2014.
Application 13/855,653 is a continuation of application No. 12/982,760, filed on Dec. 30, 2010, granted, now 8,696,644, issued on Apr. 15, 2014.
Claims priority of provisional application 61/291,345, filed on Dec. 30, 2009.
Prior Publication US 2023/0191090 A1, Jun. 22, 2023
Int. Cl. A61M 25/10 (2013.01); A61K 9/107 (2006.01); A61K 31/00 (2006.01); A61K 31/436 (2006.01); A61L 29/14 (2006.01); A61L 29/16 (2006.01)
CPC A61M 25/1018 (2013.01) [A61K 9/107 (2013.01); A61K 31/00 (2013.01); A61K 31/436 (2013.01); A61L 29/146 (2013.01); A61L 29/16 (2013.01); A61M 25/10 (2013.01); A61M 25/1011 (2013.01); A61M 25/10182 (2013.11); A61M 25/10185 (2013.11); A61M 25/10187 (2013.11); A61M 25/104 (2013.01); A61L 2300/416 (2013.01); A61L 2300/626 (2013.01); A61M 2025/1013 (2013.01); A61M 2025/105 (2013.01); A61M 2025/1075 (2013.01)] 7 Claims
OG exemplary drawing
 
1. A method for treating a coronary artery of a patient, comprising the steps of:
providing a catheter system comprising:
a balloon catheter comprising a catheter body with a distal end adapted for insertion into vasculature of a patient, a porous balloon disposed on the distal end, a proximal end adapted for connection to a fluid source, and a lumen extending from the proximal end to the balloon;
a storage chamber with a reservoir of dry drug delivery vesicles;
an inflator;
a suspension chamber in fluid communication with the inflator;
a valve operable to selectively connect the suspension chamber to the storage chamber or to the lumen of the catheter; wherein
said suspension chamber comprises a cylinder divided into two cylinder chambers by a piston, with a first of the cylinder chambers aligned for fluid communication with the valve and the storage chamber and a second of the cylinder chambers in fluid communication with the inflator;
operating the valve to align the first cylinder chamber with the storage chamber;
forcing fluid from the first cylinder chamber into the storage chamber to reconstitute the drug delivery vesicles in the storage chamber and create a suspension of reconstituted drug delivery vesicles;
using the inflator, drawing the suspension of drug delivery vesicles into the first cylinder chamber;
operating the valve to align the first cylinder chamber with the lumen of the catheter; and
navigating the distal end of the catheter to the coronary artery and inflating the balloon to affect stent deployment of a stent in the coronary artery;
operating the inflator to force additional fluid into the second cylinder chamber, to thereby force the suspension of drug delivery vesicles from the first cylinder chamber into the catheter, thereby forcing the suspension of drug delivery vesicles through a wall of the balloon and into the coronary artery proximate the balloon.