	US 12,144,894 B2
	Shape-guided controlled release and retention with structures including crosslinked poly(glycerol sebacate)
Stephanie Reed, Conshohocken, PA (US); Alexander M. Stahl, Haverford, PA (US); Manasi Chawathe Baker, Ambler, PA (US); Peter D. Gabriele, Frisco, TX (US); and Amanda K. Weber, Macungie, PA (US)
Assigned to THE SECANT GROUP, LLC, Telford, PA (US)
Filed by THE SECANT GROUP, LLC, Telford, PA (US)
Filed on Jul. 1, 2021, as Appl. No. 17/365,139.
Claims priority of provisional application 63/057,952, filed on Jul. 29, 2020.
Prior Publication US 2022/0031624 A1, Feb. 3, 2022
Int. Cl. A61K 9/48 (2006.01); A61K 45/06 (2006.01)

CPC A61K 9/4866 (2013.01) [A61K 45/06 (2013.01)]

25 Claims

1. A delivery system comprising:

a controlled release device provided in a contracted state and expandable to a three-dimensional expanded state in a stomach for retention in the stomach based on the three-dimensional expanded state, wherein the controlled release device is a single composition comprising crosslinked poly(glycerol sebacate) (PGS) and a controlled release compound loaded in the crosslinked PGS, wherein the controlled release device does not comprise biodegradable linkers.