	US 12,144,882 B2
	Method of improving the appearance of skin
Matthew Clair Ehrman, Singapore (SG); Tomohiro Hakozaki, Cincinnati, OH (US); John Erich Oblong, Loveland, OH (US); Dissanayake Mudiyanselage Mahathma Bandara Dissanayake, Mason, OH (US); and Wan Ting Chung, Singapore (SG)
Assigned to The Procter & Gamble Company, Cincinnati, OH (US)
Filed by The Procter & Gamble Company, Cincinnati, OH (US)
Filed on Nov. 29, 2022, as Appl. No. 18/070,570.
Claims priority of provisional application 63/283,733, filed on Nov. 29, 2021.
Prior Publication US 2023/0165778 A1, Jun. 1, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 8/67 (2006.01); A61K 8/23 (2006.01); A61K 8/34 (2006.01); A61K 8/365 (2006.01); A61K 8/368 (2006.01); A61K 8/49 (2006.01); A61Q 19/08 (2006.01)

CPC A61K 8/675 (2013.01) [A61K 8/23 (2013.01); A61K 8/345 (2013.01); A61K 8/365 (2013.01); A61K 8/368 (2013.01); A61K 8/4926 (2013.01); A61Q 19/08 (2013.01); A61K 2800/30 (2013.01); A61K 2800/522 (2013.01); A61K 2800/805 (2013.01)]

19 Claims

1. A method of improving the appearance of skin, comprising:

a) identifying a target portion of skin where treatment is desired;

b) applying a low-pH, aqueous skin care composition to the target portion of skin over the course of a treatment period, the composition comprising:

i) about 0.1% to about 10% of a vitamin B3 compound,

ii) about 0.1% to about 10% of a coumaric acid,

iii) a glycol co-solvent chosen from propylene glycol, dipropylene glycol, butylene glycol, pentylene glycol, hexylene glycol, ethoxydiglycol, C2-C6 polyethene glycols, or mixtures thereof; wherein the composition comprises less than 25% of the glycol co-solvent;

iv) one or more hydrotrope chosen from salicylic acid, 2,4 dihydroxybenzoic acid, 2,3 dihydroxybenzoic acid, 3-methoxy salicylic acid, salts of these, or mixtures thereof; and

v) water,

wherein the composition is free of coumaric acid crystals;

wherein the pH of the composition is less than 5.0.