US 12,144,881 B2
Cosmetic composition containing α-mangostin, method for preparation, and uses thereof
Jinxin Wang, Nanjing (CN); and Tingting Zhang, Nanjing (CN)
Assigned to CHINA PHARMACEUTICAL UNIVERSITY, Nanjing (CN)
Appl. No. 17/057,627
Filed by CHINA PHARMACEUTICAL UNIVERSITY, Nanjing (CN)
PCT Filed Jun. 24, 2019, PCT No. PCT/CN2019/092545
§ 371(c)(1), (2) Date May 12, 2021,
PCT Pub. No. WO2019/223810, PCT Pub. Date Nov. 28, 2019.
Claims priority of application No. 201810486482.4 (CN), filed on May 21, 2018.
Prior Publication US 2021/0290510 A1, Sep. 23, 2021
Int. Cl. A61K 8/49 (2006.01); A61K 8/27 (2006.01); A61K 8/29 (2006.01); A61K 8/35 (2006.01); A61K 8/37 (2006.01); A61K 8/40 (2006.01); A61Q 17/04 (2006.01); A61Q 19/02 (2006.01); A61Q 19/08 (2006.01)
CPC A61K 8/498 (2013.01) [A61Q 17/04 (2013.01); A61Q 19/08 (2013.01); A61K 8/27 (2013.01); A61K 8/29 (2013.01); A61K 2800/522 (2013.01); A61K 2800/591 (2013.01)] 7 Claims
 
1. A cosmetic composition, comprising
α-mangostin and
an organic sunscreen agent, wherein
the organic sunscreen agent has a sun protection wavelength range being complementary to a sun protection wavelength range of the α-mangostin or the organic sunscreen agent is decomposed under UV exposure;
the organic sunscreen agent consists of butyl methoxydibenzoylmethane, octyl salicylate and octocrilene; and
the content of α-mangostin is 1.81-5.99% based on a total weight of the cosmetic composition.
 
5. A method of increasing a sunscreen sun protection factor (SPF) value of an organic sunscreen agent, comprising adding α-mangostin to a cosmetic composition, wherein
the cosmetic composition comprises an organic sunscreen agent, wherein the organic sunscreen agent consists of butyl methoxydibenzoylmethane, octyl salicylate and octocrilene;
the content of α-mangostin is 1.81-5.99% based on a total weight of the cosmetic composition; and
the α-mangostin synergistically increases an SPF value of the organic sunscreen agent under UVA and UVB exposure.