US 12,144,856 B2
Compositions and methods for enhancing immune response to vaccination and improving vaccine production
Kwok Yung Yuen, Pok Fu Lam (HK); Kai Wang Kelvin To, Pok Fu Lam (HK); Shuofeng Yuan, Kennedy Town (HK); Fuk Woo Jasper Chan, Kowloon (HK); Jinxia Zhang, Tai Po New Town (HK); Fan Ngai Hung, Mid-Level (HK); and Johnson Yiu-Nam Lau, Houston, TX (US)
Assigned to VERSITECH LIMITED, Hong Kong (CN)
Filed by Versitech Limited, Telegraph Bay (HK)
Filed on Jan. 9, 2020, as Appl. No. 16/738,692.
Claims priority of provisional application 62/790,373, filed on Jan. 9, 2019.
Prior Publication US 2020/0215185 A1, Jul. 9, 2020
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 39/145 (2006.01); A61K 8/55 (2006.01); A61K 9/00 (2006.01); A61K 31/16 (2006.01); A61K 31/685 (2006.01); A61K 39/00 (2006.01); A61K 39/215 (2006.01); A61K 47/54 (2017.01); C12N 7/00 (2006.01); C12Q 1/70 (2006.01); G01N 33/94 (2006.01)
CPC A61K 39/145 (2013.01) [A61K 8/553 (2013.01); A61K 9/0014 (2013.01); A61K 31/16 (2013.01); A61K 31/685 (2013.01); A61K 39/215 (2013.01); A61K 47/544 (2017.08); C12N 7/00 (2013.01); C12Q 1/70 (2013.01); G01N 33/948 (2013.01); A61K 2039/55511 (2013.01); C12N 2760/16034 (2013.01); C12N 2770/20034 (2013.01)] 15 Claims
 
1. A method for improving an immune response to an influenza virus, comprising:
administering an adjuvant comprising miltefosine to a subject at or near a site of vaccination on the subject; and
introducing an influenza vaccine at the vaccination site, the influenza vaccine comprising a vaccinating influenza species,
wherein the adjuvant is selected to provide miltefosine in a quantity sufficient to increase the immune response relative to a vaccinated subject that has not been administered the adjuvant;
wherein the adjuvant comprising miltefosine is administered immediately prior to vaccination or from about 5 minutes to about 48 hours prior to vaccination; and
wherein the adjuvant comprising miltefosine is administered by intramuscular injection, intradermal injection, or topical application.