US 12,144,834 B2
Methods and compositions for treating gastrointestinal and inflammatory disorders
Jackie Papkoff, San Francisco, CA (US); and Jun Ma, San Francisco, CA (US)
Assigned to Xbiome Inc., New York, NY (US)
Filed by Xbiome Inc., New York, NY (US)
Filed on Sep. 13, 2019, as Appl. No. 16/570,428.
Claims priority of provisional application 62/782,666, filed on Dec. 20, 2018.
Claims priority of provisional application 62/747,391, filed on Oct. 18, 2018.
Claims priority of provisional application 62/734,495, filed on Sep. 21, 2018.
Claims priority of provisional application 62/730,792, filed on Sep. 13, 2018.
Prior Publication US 2020/0215129 A1, Jul. 9, 2020
Int. Cl. A61K 35/742 (2015.01); A61K 35/00 (2006.01); A61K 35/741 (2015.01); A61K 47/26 (2006.01); A61P 1/04 (2006.01)
CPC A61K 35/741 (2013.01) [A61K 47/26 (2013.01); A61P 1/04 (2018.01); A61K 2035/115 (2013.01)] 24 Claims
 
1. A pharmaceutical composition comprising an effective amount of a bacterial mixture, the mixture comprising an isolated Bacteroides thetaiotaomicron strain, an isolated Eubacterium hallii strain, and an isolated Roseburia hominis strain, and a pharmaceutically acceptable excipient, wherein the bacterial mixture is capable of one or more of
(a) increasing production of IL-10;
(b) increasing production of CCL-18;
(c) increasing gut barrier integrity;
(d) increasing autophagy; and
(e) reducing or attenuating production of plasma Lipocalin-2/NGAL; and
wherein the Bacteroides thetaiotaomicron strain is the live BTH01 (P118-A12a) strain comprising the 16s rRNA sequence of SEQ ID NO: 2; the Eubacterium hallii strain is the live EHA01 (P168-F1a) strain comprising the 16s rRNA sequence of SEQ ID NO: 3; and the Roseburia hominis strain is the live RHO01 (P127-H9a) strain comprising the 16s rRNA sequence of SEQ ID NO: 1, wherein the BTH01 strain is deposited at the DSMZ with the accession number DSM-32919, the EHA01 strain is deposited at the DSMZ with the accession number DSM 32920, and the RHO01 strain is deposited at the DSMZ with the accession number of DSM 32921.