US 12,144,788 B2
Visual cycle modulators
Krzysztof Palczewski, Bay Village, OH (US); Philip Kiser, Cleveland, OH (US); Jianye Zhang, Cleveland, OH (US); Mohsen Badiee, Shaker Heights, OH (US); and Gregory Tochtrop, Shaker Heights, OH (US)
Assigned to CASE WESTERN RESERVE UNIVERSITY, Cleveland, OH (US); and THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERAN AFFAIRS, Washington, DC (US)
Filed by CASE WESTERN RESERVE UNIVERSITY, Cleveland, OH (US)
Filed on Feb. 22, 2022, as Appl. No. 17/677,524.
Application 17/677,524 is a continuation of application No. 16/488,890, granted, now 11,253,489, previously published as PCT/US2018/019944, filed on Feb. 27, 2018.
Claims priority of provisional application 62/463,936, filed on Feb. 27, 2017.
Prior Publication US 2022/0175700 A1, Jun. 9, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/137 (2006.01); A61K 9/00 (2006.01); A61K 9/48 (2006.01); A61P 27/02 (2006.01)
CPC A61K 31/137 (2013.01) [A61K 9/0048 (2013.01); A61P 27/02 (2018.01)] 7 Claims
 
1. A compound of formula (I):

OG Complex Work Unit Chemistry
wherein n1 is an integer from 1 to 6;
R1 is selected from the group consisting of:

OG Complex Work Unit Chemistry
and fluoro derivatives thereof;
R2 is H, CH3, or OH;
R3 is a substituted or unsubstituted C1-C12 alkyl, C2-C12 alkenyl, C2-C12 alkynyl, C3-C6 aryl, heteroaryl, heterocyclyl, or C6-C12 alkaryl;
the dashed line is an optional bond; and
deuterated compounds and pharmaceutically acceptable salts thereof.