US 12,144,623 B2
Detecting and correcting for changes to an analyte indicator
Andrew Dehennis, Germantown, MD (US); Mark Mortellaro, Germantown, MD (US); Abhi Chavan, Germantown, MD (US); Venkata Velvadapu, Germantown, MD (US); Philip Huffstetler, Germantown, MD (US); Tina HyunJung Kim, Germantown, MD (US); and James Masciotti, Germantown, MD (US)
Assigned to Senseonics, Incorporated, Germantown, MD (US)
Filed by Senseonics, Incorporated, Germantown, MD (US)
Filed on Dec. 2, 2022, as Appl. No. 18/061,334.
Application 18/061,334 is a continuation of application No. 17/092,830, filed on Nov. 9, 2020, granted, now 11,517,230.
Application 17/092,830 is a continuation of application No. 15/957,604, filed on Apr. 19, 2018, granted, now 10,827,962, issued on Nov. 10, 2020.
Claims priority of provisional application 62/487,289, filed on Apr. 19, 2017.
Prior Publication US 2023/0103609 A1, Apr. 6, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61B 5/1495 (2006.01); A61B 5/00 (2006.01); A61B 5/07 (2006.01); A61B 5/145 (2006.01); A61B 5/1455 (2006.01); A61B 5/1459 (2006.01); A61B 5/1473 (2006.01)
CPC A61B 5/1495 (2013.01) [A61B 5/0031 (2013.01); A61B 5/076 (2013.01); A61B 5/14532 (2013.01); A61B 5/14556 (2013.01); A61B 5/1459 (2013.01); A61B 5/14546 (2013.01); A61B 5/1473 (2013.01); A61B 2560/0219 (2013.01); A61B 2560/0266 (2013.01)] 18 Claims
OG exemplary drawing
 
1. An analyte sensor for measurement of an analyte in a medium within a living animal, the analyte sensor comprising:
an analyte indicator having a first detectable property that varies in accordance with (i) an amount or concentration of the analyte in the medium and (ii) an extent to which the analyte indicator has degraded, wherein the analyte indicator comprises analyte indicator molecules; and
a degradation indicator having a second detectable property that varies in accordance with an extent to which the degradation indicator has degraded, wherein the degradation indicator comprises degradation indicator molecules, and the extent to which the degradation indicator has degraded corresponds to the extent to which the analyte indicator has degraded;
wherein the degradation indicator molecules comprise a compound of formula I:

OG Complex Work Unit Chemistry
wherein A″, B″, C″, A′, B′, C′, W′, X, Y′, and Z′ represent —CH, and the hydrogen of —CH may optionally and independently be substituted with an alkyl group;
wherein R1 and R2 are independently selected from one or more vinyl groups, alkyl vinyl groups, acrylamide groups, methacrylamide groups, or other polymerizable groups.