US 12,144,622 B2
Enzyme sensor and enzyme sensor system
Masayasu Fujioka, Minato-ku (JP); Akinori Ito, Minato-ku (JP); and Kenichi Hamada, Minato-ku (JP)
Assigned to JSR Corporation, Minato-ku (JP)
Appl. No. 16/346,734
Filed by JSR Corporation, Minato-ku (JP)
PCT Filed Nov. 7, 2017, PCT No. PCT/JP2017/040094
§ 371(c)(1), (2) Date May 1, 2019,
PCT Pub. No. WO2018/088391, PCT Pub. Date May 17, 2018.
Claims priority of application No. 2016-218104 (JP), filed on Nov. 8, 2016.
Prior Publication US 2020/0054252 A1, Feb. 20, 2020
Int. Cl. A61B 5/1486 (2006.01); A61B 5/145 (2006.01); C12Q 1/00 (2006.01); G01N 27/327 (2006.01); G01N 27/416 (2006.01); G06F 9/06 (2006.01); G06F 15/00 (2006.01)
CPC A61B 5/1486 (2013.01) [A61B 5/14517 (2013.01); C12Q 1/005 (2013.01); G01N 27/327 (2013.01); G01N 27/3277 (2013.01); G01N 27/416 (2013.01); G01N 27/3272 (2013.01); G01N 2333/904 (2013.01); G06F 9/06 (2013.01); G06F 15/00 (2013.01)] 10 Claims
OG exemplary drawing
 
1. An enzyme sensor configured to measure a measurement target substance included in a secretion of a living body, the sensor comprising:
a layered structure comprising, arranged in the following order: (a) an absorber layer configured to absorb the secretion, (b) an enzyme layer comprising an enzyme, and (c) an electrode part, the absorber layer comprising at least one selected from the group consisting of a photocurable composition and a thermosetting composition, the absorber layer further comprising a polymeric material having a chemically bound crosslinked structure, the polymeric material including at least one of:
a polymer of polyvinyl alcohol containing an azide group in a side chain;
a polymer of polysaccharide containing an azide group in a side chain; or
a polymer of polyvinyl alcohol or polysaccharide, the polymer having a crosslinked structure in which azide groups are crosslinked; and
a mediator layer between the enzyme layer and the electrode part, the mediator layer including one or more electron transport mediators selected from the group consisting of ferrocene, quinones, ferrocenecarboxylic acid, potassium ferricyanide, osmium complex, ruthenium complex, phenothiazine derivative, phenazine methosulfate derivative, p-aminophenol, meldola blue, and 2,6-dichlorophenolindophenol,
the mediator layer including (i) a first surface, wherein the enzyme layer is on the first surface and (ii) a second surface, wherein the electrode part is on the second surface,
the enzyme sensor further comprising a base material layer configured to support the electrode part, and
the base material layer being made of thermoplastic elastomer.