| CPC A61B 5/1473 (2013.01) [A61B 5/0031 (2013.01); A61B 5/14532 (2013.01); A61B 5/1495 (2013.01); G01N 33/49 (2013.01); A61B 5/1486 (2013.01); A61B 5/14865 (2013.01)] | 12 Claims | 

| 
               1. A method of operating a sensor for sensing glucose concentrations, comprising: 
            applying, using a voltage controller, multiple voltage pulses to a working electrode of a two-electrode sensor probe; 
                measuring, using a current sensor, a set of current responses corresponding to the applied multiple voltage pulses, wherein the set of current responses together form a quasi-Cottrell profile that approximates a portion of a Cottrell curve; 
                analyzing, using a processor, the set of measured current responses; 
                calibrating, using the processor, the current sensor on the basis of the analyzed set of measured current responses corresponding to the applied multiple voltage pulses, wherein calibrating the current sensor comprises comparing a characteristic of the quasi-Cottrell profile determined based on the analyzed set of measured current responses to sets of predetermined Cottrell profiles; 
                determining, using the processor, a glucose concentration value on the basis of the calibrated current sensor based on the comparison of the analyzed set of measured current responses to the sets of predetermined Cottrell profiles; and 
                transmitting, using a transmitter, the determined glucose concentration value to a receiver. 
               |