US 12,144,620 B2
System and methods for wireless drug delivery on command
Axel Scherer, Barnard, VT (US); Meisam Honarvar Nazari, Pasadena, CA (US); Muhammad Mujeeb-U-Rahman, San Gabriel, CA (US); Mehmet Sencan, Pasadena, CA (US); and Arti Gaur, Hanover, NH (US)
Assigned to CALIFORNIA INSTITUTE OF TECHNOLOGY, Pasadena, CA (US); and THE TRUSTEES OF DARTMOUTH COLLEGE, Hanover, NH (US)
Filed by CALIFORNIA INSTITUTE OF TECHNOLOGY, Pasadena, CA (US); and THE TRUSTEES OF DARTMOUTH COLLEGE, Hanover, NH (US)
Filed on Sep. 29, 2021, as Appl. No. 17/489,610.
Application 16/437,890 is a division of application No. 15/216,675, filed on Jul. 21, 2016, granted, now 10,368,788, issued on Aug. 6, 2019.
Application 17/489,610 is a continuation of application No. 16/437,890, filed on Jun. 11, 2019, granted, now 11,160,476.
Claims priority of provisional application 62/204,825, filed on Aug. 13, 2015.
Claims priority of provisional application 62/195,895, filed on Jul. 23, 2015.
Prior Publication US 2022/0160264 A1, May 26, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61B 5/1473 (2006.01); A61B 5/00 (2006.01); A61B 5/07 (2006.01); A61B 5/145 (2006.01); A61B 5/1459 (2006.01); A61B 5/1486 (2006.01); A61B 17/34 (2006.01); A61M 5/142 (2006.01); A61M 5/172 (2006.01)
CPC A61B 5/1473 (2013.01) [A61B 5/0031 (2013.01); A61B 5/076 (2013.01); A61B 5/1451 (2013.01); A61B 5/14532 (2013.01); A61B 5/1459 (2013.01); A61B 5/14865 (2013.01); A61B 5/4839 (2013.01); A61B 17/3468 (2013.01); A61M 5/14276 (2013.01); A61M 5/172 (2013.01); A61M 5/1723 (2013.01); A61B 5/14546 (2013.01); A61B 5/14735 (2013.01); A61B 2560/0219 (2013.01); A61B 2562/0209 (2013.01); A61B 2562/028 (2013.01); A61B 2562/04 (2013.01); A61B 2562/125 (2013.01); A61M 2205/3523 (2013.01); A61M 2205/8237 (2013.01); A61M 2207/00 (2013.01)] 5 Claims
OG exemplary drawing
 
1. An integrated miniaturized implantable device comprising:
a substrate for monolithic integration comprising a plurality of metal layers separated via a plurality of insulating layers;
a monolithically integrated electronic system comprising an energy storage element adapted to be charged through a wireless communication link; and
a hermetic package comprising at least two separate chambers, including at least one chamber that contains a payload and at least one other chamber that contains an electrolyte that is spaced away from the payload, the hermetic package is in its entirety fixated on the first surface of the substrate with each of the at least two separate chambers adhered to the substrate,
wherein during operation of the implantable device, the electronic system is configured to:
communicate with an external device over the wireless communication link,
extract power for the miniaturized implantable device from the wireless communication link,
charge the energy storage element based on the extracted power, and
energize an actuator via the energy storage element rupturing a seal of the hermetic package.