US 12,144,614 B2
N-type polymer based electrochemical device for direct enzymatic metabolite sensing and methods of making and using
Sahika Inal, Thuwal (SA); Anna-Maria Pappa, Cambridge (GB); and Alexander Giovannitti, London (GB)
Assigned to King Abdullah University of Science and Technology, Thuwal (SA); Institut Mines Telecom, Palaiseau (FR); and Imperial College London, London (GB)
Appl. No. 16/962,971
Filed by King Abdullah University of Science and Technology, Thuwal (SA); Institut Mines Telecom, Palaiseau (FR); and Imperial College London, London (GB)
PCT Filed Jan. 18, 2019, PCT No. PCT/IB2019/050443
§ 371(c)(1), (2) Date Jul. 17, 2020,
PCT Pub. No. WO2019/142146, PCT Pub. Date Jul. 25, 2019.
Claims priority of provisional application 62/618,794, filed on Jan. 18, 2018.
Prior Publication US 2021/0128030 A1, May 6, 2021
Int. Cl. A61B 5/145 (2006.01); A61B 5/1486 (2006.01); C12Q 1/00 (2006.01)
CPC A61B 5/14532 (2013.01) [A61B 5/14546 (2013.01); A61B 5/14865 (2013.01); C12Q 1/002 (2013.01); C12Q 1/005 (2013.01); C12Q 1/006 (2013.01); A61B 2562/125 (2013.01)] 19 Claims
OG exemplary drawing
 
1. An n-type polymer based electrochemical device for metabolite sensing comprising:
one or more source electrodes;
one or more drain electrodes;
one or more channels which comprise (a) one or more n-type polymers and (b) one or more enzymes; and
a gate electrode formed of an electrode material capable of conducting an electric current, wherein the gate electrode further comprises (a) one or more n-type polymers and (b) one or more enzymes, wherein the one or more n-type polymers and one or more enzymes are coated on a surface of the electrode material, and wherein the one or more n-type polymers are in physical contact with the one or more enzymes, allowing direct electron transfer therebetween;
wherein the source electrodes and drain electrodes are electrically connected by the one or more channels, and
wherein the electrochemical device is an organic electrochemical transistor.