US 12,474,295 B2
Analysis device and analysis method
Yufuku Matsushita, Tokyo (JP); Atsushi Kishioka, Tokyo (JP); Haruyoshi Yamamoto, Tokyo (JP); and Masafumi Miyake, Tokyo (JP)
Assigned to HITACHI HIGH-TECH CORPORATION, Tokyo (JP)
Appl. No. 17/627,910
Filed by Hitachi High-Tech Corporation, Tokyo (JP)
PCT Filed Apr. 8, 2020, PCT No. PCT/JP2020/015773
§ 371(c)(1), (2) Date Jan. 18, 2022,
PCT Pub. No. WO2021/014695, PCT Pub. Date Jan. 28, 2021.
Claims priority of application No. 2019-133863 (JP), filed on Jul. 19, 2019.
Prior Publication US 2022/0404310 A1, Dec. 22, 2022
Int. Cl. G01N 27/416 (2006.01); G01N 27/333 (2006.01)
CPC G01N 27/4163 (2013.01) [G01N 27/333 (2013.01)] 13 Claims
OG exemplary drawing
 
1. An analysis device that is configured to measure ion concentration in a sample, comprising:
a processor and a data storage;
an ion selective electrode that is configured to obtain a potential based on the ion concentration;
a reference electrode that is configured to obtain a potential based on a reference liquid;
a measurement device that is configured to measure an electromotive force between the ion selective electrode and the reference electrode;
an analyzer that is configured to analyze a potential change of the electromotive force in a certain time region,
the processor in communication with at least the measurement device and the analyzer;
a flow path for supplying the sample to the ion selective electrode; and
the data storage configured to store abnormality analysis data indicating a relation between the potential change and an abnormality of the analysis device,
wherein the analyzer is configured to
acquire a first parameter for the potential change of the electromotive force measured by the measurement device, and
analyze the abnormality of the analysis device based on the first parameter and the abnormality analysis data stored in advance in the data storage,
wherein
the analyzer is configured to acquire the first parameter by analyzing a frequency of the potential change in the time region and analyzing an intensity distribution of the frequency of the potential change,
the analysis device further comprises a mechanism that is configured to intentionally mix air bubbles into the flow path, or a mechanism that is configured to intentionally apply a vibration to the analysis device, or a mechanism that is configured to intentionally apply electrical noise to the analysis device, and
the analyzer is configured to
acquire the first parameter for the potential change of the electromotive force measured by the measurement device when the air bubbles are mixed into the flow path or when the vibration is applied or when the electrical noise is applied before normal measurement of the sample, and
evaluate a degree of an influence of the mixing of the air bubbles or of the vibration or of the electrical noise on the potential change by comparing the first parameter when the air bubbles are mixed into the flow path or when the vibration is applied or when the electrical noise is applied, with an abnormality threshold value of the first parameter stored in the data storage to obtain, and then store in the data storage, an abnormality threshold value indicating said degree of influence on the first parameter.