US 12,474,287 B2
Detection device and methods of use thereof
Srikanth Rao Agnihotra, Tyngsboro, MA (US); Madanodaya Sundhoro, Lowell, MA (US); Brent Amberger, Dracut, MA (US); Abigail Barnes, Madison, WI (US); Joseph Belbruno, Hanover, NH (US); Seung Hyuk Noh, Providence, RI (US); Jeanette Numbers, Providence, RI (US); and Elizabeth Soucy, Seattle, WA (US)
Assigned to Amulet, Inc., Madison, WI (US)
Filed by Amulet, Inc., Madison, WI (US)
Filed on Feb. 8, 2024, as Appl. No. 18/436,357.
Application 18/436,357 is a continuation of application No. 16/609,943, granted, now 11,940,403, previously published as PCT/US2018/030494, filed on May 1, 2018.
Claims priority of provisional application 62/500,412, filed on May 2, 2017.
Prior Publication US 2024/0219336 A1, Jul. 4, 2024
Int. Cl. G01N 27/12 (2006.01); G01N 27/04 (2006.01); G01N 33/02 (2006.01); G01N 33/68 (2006.01); C08K 3/04 (2006.01)
CPC G01N 27/126 (2013.01) [G01N 27/045 (2013.01); C08K 3/041 (2017.05); C08K 2201/001 (2013.01); G01N 33/02 (2013.01); G01N 33/68 (2013.01); G01N 2600/00 (2013.01)] 17 Claims
OG exemplary drawing
 
1. A portable food allergen and/or ingredient detection system comprising:
a portion comprising a body, wherein the body comprises
a reservoir comprising a liquid,
a chamber for mixing the liquid with a food sample, and
a sensor, the sensor comprising
a first chip comprising a molecularly imprinted polymer layer comprising receptor sites imprinted in a first surface of the polymer, the receptor sites configured to accept a trace molecule of the food allergen and/or ingredient; and
a second chip comprising a non-imprinted polymer layer, wherein the non-imprinted polymer layer is not imprinted with receptor sites,
wherein the first chip detects the presence of the trace molecule upon binding to one or more of the receptor sites on the molecularly imprinted polymer,
wherein a first portion of the sensor containing the first and second chips is in contact with the reservoir, and a second portion of the sensor is outside of the body; and
a re-usable processing device portion which communicatively couples to the second portion of the sensor outside of the body to determine the presence of the food allergen and/or ingredient by determining a response difference between a response of the molecularly imprinted polymer layer and a response of the non-imprinted polymer layer in the presence of the food allergen and/or ingredient.