	US 12,473,378 B2
	Antigen-binding molecules comprising unpaired variable domains
Stephen Dowd, Cambridge (GB); Andrew Lindsay Wood, Cambridge (GB); E-Chiang Lee, Cambridge (GB); Hannah Linton Craig, Cambridge (GB); and Allan Bradley, Cambridge (GB)
Assigned to Kymab Limited, Cambridge (GB)
Appl. No. 17/274,103
Filed by Kymab Limited, Cambridge (GB)
PCT Filed Sep. 5, 2019, PCT No. PCT/EP2019/073767 § 371(c)(1), (2) Date Mar. 5, 2021, PCT Pub. No. WO2020/049128, PCT Pub. Date Mar. 12, 2020.
Claims priority of application No. 1814529 (GB), filed on Sep. 6, 2018.
Prior Publication US 2021/0395397 A1, Dec. 23, 2021
Int. Cl. C07K 16/46 (2006.01); A01K 67/0278 (2024.01); C12N 15/85 (2006.01)

CPC C07K 16/461 (2013.01) [A01K 67/0278 (2013.01); C12N 15/8509 (2013.01); A01K 2207/15 (2013.01); A01K 2217/072 (2013.01); A01K 2217/15 (2013.01); A01K 2227/105 (2013.01); C07K 2317/51 (2013.01); C07K 2317/64 (2013.01)]

20 Claims

1. A non-human animal or non-human animal cell having a genome comprising:

a plurality of human variable region gene segments capable of rearrangement to encode a variable domain, upstream of DNA encoding an immunoglobulin constant region comprising a CH1 domain, and

(i) a gene encoding a CL domain which lacks functional expression of variable region gene segments, or (ii) a gene encoding the immunoglobulin domain of λ5.