| CPC C07F 9/6561 (2013.01) [A61P 31/12 (2018.01)] | 33 Claims |
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1. A compound of Formula I:
 or a pharmaceutically acceptable salt thereof, wherein:
Z1 is —CH2— or —CH2—CH2—;
Z2 is —CH2— or —CH2—CH2—;
X is a bond, —O—, —(CR12AR12B)q—, —O(CR12AR12B)q—, or —OCR12AR12B—(CR13═CR14)—; wherein
each R12A is independently H or C1-C6 alkyl;
each R12B is independently H or C1-C6 alkyl; or
R12A and R12B on the same carbon are joined together to form a C3-C6 cycloalkylene;
R13 is H, C1-C6 alkyl, or phenyl;
R14 is H, C1-C6 alkyl, or phenyl; and
q is 1 or 2;
R1 is C3-C10 cycloalkyl, 4 to 6 membered heterocyclyl containing one, two or three heteroatoms selected from N, O, and S, or 5-10 membered heteroaryl containing one, two or three heteroatoms selected from N, S, and O; wherein the R1 group is substituted with one or two R1A groups;
wherein each R1A is independently a C1-C3 alkyl, phenyl, halo, C1-C3 alkoxy, cyano, or C1-C3haloalkyl; or wherein two R1A on same or adjacent carbons are joined together to form a 3 to 6 membered cycloalkyl or 4 to 6 membered heterocyclyl ring containing one, two or three heteroatoms selected from N, S, and O;
R2 is H or C1-C3 alkyl;
Y is absent;
R3 is H, C1-C3 alkyl, halo, C1-C3 haloalkyl, or C3-C6 cycloalkyl;
each R4 is independently H, C1-C3 alkyl, halo, C1-C3 haloalkyl, or C3-C6 cycloalkyl; or R4 group together with the R4 group of one adjacent carbon atom forms a double bond;
each R5 is independently H, C1-C3 alkyl, halo, C1-C3 haloalkyl, or C3-C6 cycloalkyl;
R6 is H;
R7 is H; and
m is an integer from 10 to 21.
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