US 12,473,312 B2
Agonists of peroxisome proliferator-activated receptor alpha (PPAR+60 ) and methods of use
Adam Duerfeldt, Norman, OK (US); Xiaozheng Dou, Norman, OK (US); and Ziwei Hu, St. Paul, MN (US)
Assigned to The Board of Regents of the University of Oklahoma, Norman, OK (US)
Filed by The Board of Regents of the University of Oklahoma, Norman, OK (US)
Filed on Jul. 28, 2022, as Appl. No. 17/876,243.
Application 17/876,243 is a continuation in part of application No. 16/981,483, granted, now 11,447,452, previously published as PCT/US2019/022400, filed on Mar. 15, 2019.
Claims priority of provisional application 62/643,998, filed on Mar. 16, 2018.
Prior Publication US 2022/0389036 A1, Dec. 8, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61P 29/00 (2006.01); C07F 9/30 (2006.01); C07F 9/38 (2006.01)
CPC C07F 9/3808 (2013.01) [A61P 29/00 (2018.01); C07F 9/301 (2013.01)] 17 Claims
 
1. A compound, comprising the chemical structure:

OG Complex Work Unit Chemistry
wherein:
X=COOH,
R1=4-F, 2,4-diF, 3,4-diF, 3,5-diF, or 4-OCH3,
R2=H, 3-F, 3-Cl, 2-CH3 or 3-CH3,
R3=H or F, and
R4=H or CH3.