US 12,472,284 B2
Structured gels
Richard Oreffo, Southampton (GB); Jonathan Dawson, Southampton (GB); Nicholas Evans, Southampton (GB); and Roxanna Sharon Ramnarine Sanchez, Southampton (GB)
Assigned to University of Southampton, Southampton (GB)
Appl. No. 17/277,690
Filed by UNIVERSITY OF SOUTHAMPTON, Southampton (GB)
PCT Filed Sep. 20, 2019, PCT No. PCT/GB2019/052647
§ 371(c)(1), (2) Date Mar. 18, 2021,
PCT Pub. No. WO2020/058724, PCT Pub. Date Mar. 26, 2020.
Claims priority of application No. 1815369 (GB), filed on Sep. 20, 2018.
Prior Publication US 2022/0096715 A1, Mar. 31, 2022
Int. Cl. A61L 27/54 (2006.01); A61K 31/4188 (2006.01); A61K 38/16 (2006.01); A61K 38/17 (2006.01); A61K 38/18 (2006.01); A61L 27/44 (2006.01); C07K 16/28 (2006.01)
CPC A61L 27/446 (2013.01) [A61K 31/4188 (2013.01); A61K 38/164 (2013.01); A61K 38/1709 (2013.01); A61K 38/1875 (2013.01); A61L 27/54 (2013.01); C07K 16/283 (2013.01); A61L 2300/204 (2013.01); A61L 2300/252 (2013.01); A61L 2300/256 (2013.01); A61L 2300/442 (2013.01); A61L 2400/12 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A method for forming a spatially structured clay-nanoparticle gel comprising one or more spatially structured molecule species, the method comprising:
forming a spatially structured clay-nanoparticle gel comprising protein, by
providing a colloidal solution of clay-nanoparticles, and
immersing the colloidal solution of clay-nanoparticles into an aqueous assembly solution without mixing and allowing the colloidal solution of clay-nanoparticles to set via protein diffusion into a gel within the aqueous assembly solution,
wherein a protein is provided in the aqueous assembly solution prior to, concurrently, or after the immersion of the colloidal solution of clay-nanoparticles into the aqueous assembly solution, thereby forming a clay-nanoparticle gel comprising the protein; and
loading the clay-nanoparticle gel comprising protein with additional molecules comprising the step of immersing the clay-nanoparticle gel comprising protein into an aqueous loading solution,
wherein the additional molecules are provided in the aqueous loading solution prior to, concurrently, or after the immersion of the clay-nanoparticle gel comprising protein into the aqueous loading solution, such that the additional molecules are absorbed into the clay-nanoparticle gel and spatially structured therein.