US 12,472,269 B2
Liver-specific inducible promoters and methods of use thereof
Michael Roberts, Midlothian (GB); Graham Whyteside, Midlothian (GB); and Anne Braae, Midlothian (GB)
Assigned to ASKBIO INC.
Appl. No. 17/423,693
Filed by ASKBIO INC., Research Triangle Park, NC (US)
PCT Filed Jan. 20, 2020, PCT No. PCT/GB2020/050107
§ 371(c)(1), (2) Date Jul. 16, 2021,
PCT Pub. No. WO2020/148555, PCT Pub. Date Jul. 23, 2020.
Claims priority of application No. 1900741 (GB), filed on Jan. 18, 2019.
Prior Publication US 2022/0111078 A1, Apr. 14, 2022
Int. Cl. A61K 48/00 (2006.01); A61P 1/16 (2006.01); C12N 15/86 (2006.01)
CPC A61K 48/0058 (2013.01) [A61P 1/16 (2018.01); C12N 15/86 (2013.01)] 13 Claims
OG exemplary drawing
 
1. A vector comprising an expression cassette, the expression cassette comprising a synthetic liver-specific inducible promoter operably linked to a gene, the synthetic liver-specific inducible promoter comprising the at least one cis-regulatory module (CRM) comprising or consisting of a sequence selected from the group consisting of: SEQ ID NO: 42, SEQ ID NO: 43, SEQ ID NO: 44, SEQ ID NO: 45, SEQ ID NO: 46, and SEQ ID NO: 47.