	US 12,472,267 B2
	Compositions containing nucleic acid nanoparticles with modular functionality
James Luke Rushworth, London (GB); George William Foot, Dorchester (GB); Anna Perdrix Rosell, London (GB); and Zuzanna Aleksandra Brzosko, London (GB)
Assigned to SIXFOLD BIOSCIENCE LTD., London (GB)
Filed by Sixfold Bioscience Ltd., London (GB)
Filed on May 6, 2022, as Appl. No. 17/738,561.
Application 17/738,561 is a continuation of application No. 17/241,920, filed on Apr. 27, 2021, granted, now 11,357,865.
Claims priority of provisional application 63/015,735, filed on Apr. 27, 2020.
Prior Publication US 2022/0370635 A1, Nov. 24, 2022
Int. Cl. A61K 47/69 (2017.01); A61K 47/22 (2006.01); A61K 47/26 (2006.01); C12N 15/113 (2010.01); C12N 15/115 (2010.01)

CPC A61K 47/6929 (2017.08) [A61K 47/22 (2013.01); A61K 47/26 (2013.01); C12N 15/113 (2013.01); C12N 15/115 (2013.01); C12N 2310/14 (2013.01); C12N 2310/16 (2013.01); C12N 2310/3519 (2013.01)]

19 Claims

1. A composition comprising: an oligonucleotide covalently linked to one or more cargo molecules, wherein the oligonucleotide is RNA and the one or more cargo molecules is an siRNA duplex molecule or an ASO, and wherein the one or more cargo molecules is covalently linked to the oligonucleotide via an orthogonal click chemistry reaction between a modified nucleotide at a terminal end of the RNA and a modified nucleotide at a terminal end of the siRNA duplex molecule or ASO.