US 12,472,214 B2
Bacterial strains, the compositions thereof and use thereof in a method for the treatment of vitamin D deficiency, and disorders associated therewith
Andrea Biffi, Trezzano Rosa (IT); and Walter Fiore, Trezzano Rosa (IT)
Assigned to ALFASIGMA S.P.A, Bologna (IT)
Appl. No. 17/798,882
Filed by ALFASIGMA S.P.A., Bologna (IT)
PCT Filed Apr. 28, 2021, PCT No. PCT/IB2021/052523
§ 371(c)(1), (2) Date Aug. 10, 2022,
PCT Pub. No. WO2021/191855, PCT Pub. Date Sep. 30, 2021.
Claims priority of application No. 102020000006448 (IT), filed on Mar. 26, 2020.
Prior Publication US 2023/0190833 A1, Jun. 22, 2023
Int. Cl. A61K 35/747 (2015.01); A61K 31/593 (2006.01); A61P 3/02 (2006.01)
CPC A61K 35/747 (2013.01) [A61K 31/593 (2013.01); A61P 3/02 (2018.01)] 6 Claims
 
1. A method of treating a patient having a vitamin D deficiency and/or insufficiency (or hypovitaminosis D) and/or of a disease, symptom and/or disorder associated with said vitamin D deficiency, comprising administering to the patient a bacterial strain belongs to the species Lactobacillus paracasei, reclassified Lacticaseibacillus paracasei, wherein said bacterial strain belongs to the species Lactobacillus paracasei is selected from the group consisting of:
a bacterial strain belonging to the species Lactobacillus paracasei identified as Lactobacillus paracasei DG® and deposited at the National Collection of Cultures of Microorganisms of the Pasteur Institute in Paris under the accession number CNCM 1-1572 and name Lactobacillus casei DG® sub. casei, and
a bacterial strain belonging to the species Lactobacillus paracasei identified as Lactobacillus paracasei LPC-SOl® and deposited at Deutsche Sammlung van Mikroorganismen und Zellkulturen GmbH (DSMZ) under the accession number DSM 26760,
and a mixture thereof thereby increasing vitamin D levels in the subject.