	US 12,472,161 B2
	Storage stable mixtures, method of improving retention of a compound and use of rice hulls and/or rice bran to enhance retention of a compound
Dominik Josef Brunner, Kaiseraugst (CH); Laure Clasadonte, Kaiseraugst (CH); Martin Reto Gadient, Kaiseraugst (CH); and Roland Schuepfer, Kaiseraugst (CH)
Assigned to DSM IP ASSETS B.V., (NL)
Appl. No. 16/772,948
Filed by DSM IP ASSETS B.V., Heerlen (NL)
PCT Filed Dec. 17, 2018, PCT No. PCT/EP2018/085205 § 371(c)(1), (2) Date Jun. 15, 2020, PCT Pub. No. WO2019/121515, PCT Pub. Date Jun. 27, 2019.
Claims priority of application No. 17207908 (EP), filed on Dec. 18, 2017.
Prior Publication US 2021/0161849 A1, Jun. 3, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/21 (2006.01); A23K 10/37 (2016.01); A23K 20/10 (2016.01); A23K 20/105 (2016.01); A23K 20/111 (2016.01); A23K 20/132 (2016.01); A23K 20/142 (2016.01); A23K 20/158 (2016.01); A23K 20/174 (2016.01); A23K 20/28 (2016.01); A23K 30/00 (2016.01); A23K 50/10 (2016.01); A23L 7/10 (2016.01); A61K 9/08 (2006.01); A61K 9/16 (2006.01); A61K 45/06 (2006.01); A61K 47/10 (2017.01); A61K 47/46 (2006.01)

CPC A61K 31/21 (2013.01) [A23K 10/37 (2016.05); A23K 20/10 (2016.05); A23K 20/105 (2016.05); A23K 20/111 (2016.05); A23K 20/132 (2016.05); A23K 20/142 (2016.05); A23K 20/158 (2016.05); A23K 20/174 (2016.05); A23K 20/28 (2016.05); A23K 30/00 (2016.05); A23K 50/10 (2016.05); A23L 7/115 (2016.08); A61K 9/08 (2013.01); A61K 9/1611 (2013.01); A61K 9/1617 (2013.01); A61K 9/1664 (2013.01); A61K 45/06 (2013.01); A61K 47/10 (2013.01); A61K 47/46 (2013.01); Y02P 60/22 (2015.11); Y02P 60/87 (2015.11)]

21 Claims

1. A storage stable mixture comprising:

(a) a powderous formulation; and

(b) rice hulls and/or rice bran;

wherein the powderous formulation comprises:

(i) silica, and

(ii) 1,3-propanediol mononitrate (PDMN) as an active ingredient absorbed on the silica; and

wherein the rice hulls and/or rice bran are present in an amount to provide a weight ratio (w/w) of the rice hulls and/or rice bran to the PDMN active ingredient of 200:1 to 1:1 sufficient to reduce evaporation and thereby provide a retention of the PDMN active ingredient in the powderous formulation which is at least 70% when stored in a closed polyethylene or aluminum bag for at least 4 weeks at 25° C. and 50% relative humidity.

15. A method of improving retention of propanediol mononitrate in a powderous formulation comprising the propanediol mononitrate, the method comprising the steps of:

(a) providing a powderous formulation comprising silica and 1,3-propanediol mononitrate (PDMN) as an active ingredient absorbed on the silica, and

(b) admixing the powderous formulation comprising the silica and PDMN active ingredient absorbed on the silica with rice hulls and/or rice bran in amounts so as to achieve a weight ratio (w/w) of the rice hulls and/or the rice bran to the powderous formulation in a range of 50:1 to 1:10 and to achieve a weight ratio (w/w) of the rice hulls and/or rice bran to the PDMN active ingredient of 200:1 to 1:1 sufficient to reduce evaporation and thereby provide a retention of the PDMN active ingredient in the powderous formulation which is at least 70% when stored in a closed polyethylene or aluminum bag for at least 4 weeks at 25° C. and 50% relative humidity.