US 12,472,133 B2
Method for producing 1,3-butylene glycol, and 1,3-butylene glycol product
Masahiko Shimizu, Tokyo (JP); Satoshi Kusakabe, Tokyo (JP); and Ryuji Saitou, Tokyo (JP)
Assigned to DAICEL CORPORATION, Osaka (JP)
Appl. No. 17/788,968
Filed by DAICEL CORPORATION, Osaka (JP)
PCT Filed Dec. 23, 2020, PCT No. PCT/JP2020/048185
§ 371(c)(1), (2) Date Jun. 24, 2022,
PCT Pub. No. WO2021/132342, PCT Pub. Date Jul. 1, 2021.
Claims priority of application No. 2019-239974 (JP), filed on Dec. 28, 2019; application No. 2019-239975 (JP), filed on Dec. 28, 2019; application No. 2019-239976 (JP), filed on Dec. 28, 2019; application No. 2019-239977 (JP), filed on Dec. 28, 2019; application No. 2019-239978 (JP), filed on Dec. 28, 2019; application No. 2019-239979 (JP), filed on Dec. 28, 2019; application No. 2020-006660 (JP), filed on Jan. 20, 2020; and application No. 2020-018910 (JP), filed on Feb. 6, 2020.
Prior Publication US 2023/0033469 A1, Feb. 2, 2023
Int. Cl. A61K 8/34 (2006.01); A61Q 19/00 (2006.01); B01D 3/42 (2006.01); C07C 29/141 (2006.01); C07C 29/60 (2006.01); C07C 29/80 (2006.01); C07C 29/84 (2006.01); C07C 31/20 (2006.01)
CPC A61K 8/345 (2013.01) [A61Q 19/00 (2013.01); A61Q 19/007 (2013.01); B01D 3/4205 (2013.01); C07C 29/141 (2013.01); C07C 29/60 (2013.01); C07C 29/80 (2013.01); C07C 29/84 (2013.01); C07C 31/207 (2013.01); A61K 2800/10 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A method for producing 1,3-butylene glycol to yield purified 1,3-butylene glycol from a reaction crude liquid including 1,3-butylene glycol, the method comprising:
performing dehydration including removing water by distillation;
removing a high boiling point component including removing a high boiling point component by distillation; and
performing product distillation to yield purified 1,3-butylene glycol,
wherein, in a high boiling point component removal column for use in the removing the high boiling point component, a charged liquid including 1,3-butylene glycol is distilled under a condition that a reflux ratio is 0.1 or greater and not greater than 100 in a case where a concentration of 1,3-butylene glycol in the charged liquid is 95% or less, or a reflux ratio is 0.05 or greater and not greater than 100 in a case where a concentration of 1,3-butylene glycol in the charged liquid is greater than 95%, and high-purity 1,3-butylene glycol is distilled off from above a charging plate, and a liquid in which a high boiling point component is concentrated is extracted from below the charging plate.