US 12,471,808 B1
System and method for non-invasive blood glucose monitoring
Stephen E. Saddow, Land O'Lakes, FL (US); Fabiola Araujo Cespedes, Temple Terrace, FL (US); Gokhan Mumcu, Tampa, FL (US); and Christopher Leroy Frewin, Ann Arbor, MI (US)
Assigned to University of South Florida, Tampa, FL (US)
Filed by University of South Florida, Tampa, FL (US)
Filed on Nov. 5, 2021, as Appl. No. 17/520,183.
Application 17/520,183 is a continuation in part of application No. 16/262,836, filed on Jan. 30, 2019, granted, now 11,185,261.
Claims priority of provisional application 62/623,771, filed on Jan. 30, 2018.
This patent is subject to a terminal disclaimer.
Int. Cl. A61B 5/145 (2006.01); A61B 5/00 (2006.01); A61B 5/05 (2021.01); H01Q 1/24 (2006.01); H01Q 1/27 (2006.01); H01Q 9/04 (2006.01)
CPC A61B 5/14532 (2013.01) [A61B 5/05 (2013.01); A61B 5/6824 (2013.01); A61B 5/6833 (2013.01); A61B 5/742 (2013.01); H01Q 1/24 (2013.01); H01Q 1/273 (2013.01); H01Q 9/0407 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A non-invasive glucose monitoring system, the system comprising:
a patch antenna configured to be positioned exterior to a subject and aligned with a blood vessel of the subject;
a radio frequency (RF) synthesizer to generate a radio frequency signal having a frequency sweep, wherein the frequency sweep of the RF synthesizer is between about 5.725 GHz and about 5.875 GHz at 1 MHz intervals;
a first demodulating logarithmic amplifier;
a second demodulating logarithmic amplifier;
a bi-directional coupler to receive the RF signal from the RF synthesizer, for each frequency of the frequency sweep, to transmit a fraction of the RF signal to the patch antenna and to transmit a forward coupled RF signal to the first demodulating logarithmic amplifier;
the bi-directional coupler further to receive a reverse coupled RF signal comprising power reflection measurements from the patch antenna in response to the frequency sweep of the RF synthesizer and to transmit the reverse coupled RF signal to the second demodulating logarithmic amplifier;
the first demodulating logarithmic amplifier to convert the forward coupled RF signal to a corresponding forward voltage and the second demodulating logarithmic amplifier to convert the reverse coupled RF signal to a corresponding reverse voltage;
a microcontroller coupled to the first demodulating logarithmic amplifier and to the second demodulating logarithmic amplifier, the microcontroller to determine a resonant frequency of the patch antenna based upon the forward voltage and the reverse voltage; and
the microcontroller further to estimate a glucose level of blood present in the blood vessel of the subject based upon the resonant frequency of the patch antenna.