US 12,471,778 B1
Optical pumping-based multimodal fusion detection apparatus
Chengpeng Chai, Hangzhou (CN); Xi Yang, Hangzhou (CN); Yun-Hsuan Chen, Hangzhou (CN); and Mohamad Sawan, Hangzhou (CN)
Assigned to WESTLAKE UNIVERSITY, Hangzhou (CN)
Filed by Westlake University, Hangzhou (CN)
Filed on Apr. 17, 2025, as Appl. No. 19/181,354.
Claims priority of application No. 202411249231.6 (CN), filed on Sep. 6, 2024.
Int. Cl. A61B 5/00 (2006.01); A61B 5/145 (2006.01); A61B 5/246 (2021.01)
CPC A61B 5/0035 (2013.01) [A61B 5/0042 (2013.01); A61B 5/0095 (2013.01); A61B 5/14542 (2013.01); A61B 5/246 (2021.01); A61B 2562/0223 (2013.01)] 11 Claims
OG exemplary drawing
 
1. An optical pumping-based multimodal fusion detection apparatus, comprising:
a laser generation module, a laser path control module, an atomic vapor cell, a photodetection module, an ultrasonic detection module, and a data processing module;
wherein the laser generation module comprises a first laser emission port and a second pulsed laser emission port, the first laser emission port is optically aligned with a first laser entry port of the atomic vapor cell, the second pulsed laser emission port is optically aligned with a path control incident port comprised in the laser path control module, a detection port of the atomic vapor cell is optically aligned with a preset region, and the atomic vapor cell is a gas cell based on an optical pumping magnetometer principle, the atomic vapor cell is configured to detect the preset region, the preset region corresponds to a set position of a measured part of a subject;
the laser path control module further comprises a path control emission port, the path control emission port is optically aligned with the preset region;
a laser receiving port of the photodetection module is optically aligned with a first laser exit port of the atomic vapor cell;
a detection point of the ultrasonic detection module is associated with the preset region and is used to enable the ultrasonic detection module to detect the preset region;
the photodetection module and the ultrasonic detection module are respectively electrically connected to the data processing module, and the photodetection module, ultrasonic detection module, and data processing module collectively function as a detection module;
wherein the detection module is configured to collect a laser intensity and polarization variation signals corresponding to the first laser after propagation through the atomic vapor cell and output local magnetic field variations in a brain of the subject caused by neural discharges based on the laser intensity and polarization variation signals, the detection module is further configured to collect ultrasonic signals corresponding to an interaction between the second pulsed laser and the measured part, and output blood oxygen signals of the subject based on the ultrasonic signals; and
the data processing module is implemented by a data acquisition device, the laser generation module is implemented using a third pulsed laser device, and a pulsed laser generated by the third pulsed laser device propagates through a beam splitter to respectively produce the first laser and the second pulsed laser.