US 12,140,520 B2
Nanosensors and use thereof
Qimin Quan, Newton, MA (US); Joseph Wilkinson, Windham, NH (US); Joshua A. Ritchey, Melrose, MA (US); and John Boyce, Boston, MA (US)
Assigned to NanoMosaic Inc., Waltham, MA (US)
Appl. No. 17/434,287
Filed by NanoMosaic Inc., Waltham, MA (US)
PCT Filed Feb. 27, 2020, PCT No. PCT/US2020/020204
§ 371(c)(1), (2) Date Aug. 26, 2021,
PCT Pub. No. WO2020/176793, PCT Pub. Date Sep. 3, 2020.
Claims priority of provisional application 62/811,543, filed on Feb. 28, 2019.
Claims priority of provisional application 62/811,559, filed on Feb. 28, 2019.
Claims priority of provisional application 62/811,579, filed on Feb. 28, 2019.
Claims priority of provisional application 62/811,041, filed on Feb. 27, 2019.
Prior Publication US 2022/0128446 A1, Apr. 28, 2022
Int. Cl. G01N 15/06 (2024.01); B82Y 15/00 (2011.01); G01N 15/01 (2024.01); G01N 21/25 (2006.01); G01N 21/552 (2014.01); G01N 33/68 (2006.01)
CPC G01N 15/0612 (2013.01) [G01N 21/25 (2013.01); G01N 21/554 (2013.01); B82Y 15/00 (2013.01); G01N 15/01 (2024.01); G01N 33/6863 (2013.01); G01N 2333/4737 (2013.01); G01N 2333/525 (2013.01); G01N 2333/5412 (2013.01)] 30 Claims
OG exemplary drawing
 
1. A sensor for detecting presence, or quantifying an amount, of an analyte in a sample of interest, the sensor comprising:
a first region and a second region,
the first region comprising a first series of nanostructures capable of binding the analyte and producing a detectable signal indicative of a concentration of the analyte in the sample within a first concentration range, and
the second region comprising a second series of different nanostructures capable of binding the analyte and producing a detectable signal indicative of a concentration of the analyte in the sample within a second, different concentration range,
wherein (i) the sensor is capable of quantifying the amount of analyte in a sample across both the first concentration range and the second concentration range and (ii) the nanostructures are integral with at least one of a planar support or a flexible substrate.