| CPC G01N 1/312 (2013.01) [B01L 3/502 (2013.01); G01N 1/31 (2013.01); B01L 2300/043 (2013.01); B01L 2300/047 (2013.01); B01L 2300/0609 (2013.01); B01L 2300/0809 (2013.01); G01N 2001/302 (2013.01)] | 20 Claims |

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1. A sample processing assembly for treatment of a sample on a substrate, the assembly including:
a mounting surface for the substrate;
a closure body configured to releasably retain a cover member, the closure body being movable between an open position and a closed position;
a force distribution member;
a closing means for applying a closing force to the closure body to move it to a closed position; and
an opening means for applying an opening force to the closure body;
wherein, when a substrate is placed in the assembly and the closure body is in the closed position while retaining a cover member, a reaction chamber is formed for processing a sample;
wherein the force distribution member is coupled with the closure body in a manner that permits rocking of the force distribution member in a plane that is orthogonal to the substrate when in the closed position; and
wherein the force distribution member distributes the closing force applied to the closure body evenly so that when in the closed position, a seal forms at a junction between the cover member and the substrate.
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