	US 12,139,767 B2
	Composition and methods for predicting necrotizing enterocolitis in preterm infants
Bing Ma, Clarksville, MD (US); Rose Viscardi, Timonium, MD (US); and Jacques Ravel, Laurel, MD (US)
Assigned to UNIVERSITY OF MARYLAND, BALTIMORE, Baltimore, MD (US)
Appl. No. 17/056,562
Filed by Bing Ma, Clarksville, MD (US); Rose Viscardi, Timonium, MD (US); and Jacques Ravel, Laurel, MD (US)
PCT Filed May 22, 2019, PCT No. PCT/US2019/033488 § 371(c)(1), (2) Date Nov. 18, 2020, PCT Pub. No. WO2019/226751, PCT Pub. Date Nov. 28, 2019.
Claims priority of provisional application 62/674,782, filed on May 22, 2018.
Prior Publication US 2021/0254137 A1, Aug. 19, 2021
Int. Cl. A61K 35/745 (2015.01); C12Q 1/689 (2018.01)

CPC C12Q 1/689 (2013.01) [C12Q 2600/106 (2013.01); C12Q 2600/158 (2013.01)]

26 Claims

1. A method of treating or preventing high intestinal permeability in a subject comprising:

(a) determining the amount of Clostridiales and/or Bifidobacteriales bacteria in a sample obtained from a subject, and administering a therapeutically effective amount of a treatment or preventive agent for high intestinal permeability (IP) to the subject when the amount of Clostridiales and/or Bifidobacteriales bacteria in the sample is about 5% or less by relative abundance of the total amount of bacteria; or

(b) determining the amount of Clostridiales and/or Bifidobacteriales bacteria in samples obtained from a subject at two or more time points and administering a therapeutically effective amount of a treatment or preventive agent for high intestinal permeability to the subject when the amount of Clostridiales and/or Bifidobacteriales bacteria in the samples decreases over time.