US 12,139,702 B2
Adaptive electrode arrangement and method for implementation in a cell incubator system and applications thereof
Chuck Z. Li, Thousand Oaks, CA (US); Brandon Zachary Sarich, Thousand Oaks, CA (US); and Phillip Ng, Newbury Park, CA (US)
Assigned to AMGEN INC., Thousand Oaks, CA (US)
Filed by AMGEN INC., Thousand Oaks, CA (US)
Filed on Sep. 30, 2022, as Appl. No. 17/957,982.
Application 17/957,982 is a division of application No. 16/639,016, granted, now 11,492,609, previously published as PCT/US2018/045587, filed on Aug. 7, 2018.
Claims priority of provisional application 62/546,445, filed on Aug. 16, 2017.
Prior Publication US 2023/0022041 A1, Jan. 26, 2023
Int. Cl. C12M 3/00 (2006.01); C12M 1/32 (2006.01); C12M 1/42 (2006.01); C12N 5/00 (2006.01); C12N 5/077 (2010.01); C12N 13/00 (2006.01); G01N 33/50 (2006.01)
CPC C12N 13/00 (2013.01) [C12M 1/42 (2013.01); C12M 23/12 (2013.01); C12M 35/02 (2013.01); C12N 5/0657 (2013.01); G01N 33/5008 (2013.01); G01N 33/5061 (2013.01); C12N 2506/45 (2013.01); C12N 2529/00 (2013.01)] 10 Claims
OG exemplary drawing
 
1. A microwell plate assembly comprising:
a microwell plate having a plurality of wells, each well of the plurality of wells having a bottom portion; and
an array of adaptive electrode arrangements for introducing an electric field into each well of the plurality of wells, each adaptive electrode arrangement including:
a pair of electrodes disposed within the well of the plurality of wells and configured to be coupled to one of a circuit board or a cover plate, each electrode of the pair of electrodes having a distal end and independently and axially displaceable relative to each other and the bottom portion of the well;
wherein the distal end of each electrode of the pair of electrodes is in constant contact with the bottom portion of the well, ensuring a uniform and constant electric field is applied within the well, and the distal end is moveable relative to one of the circuit board or the cover plate.