US 12,138,623 B2
Adjacent dual biological nanopore readers
John Andrew Wisniewski, South Salt Lake, UT (US); Vanja Panic, Salt Lake City, UT (US); Eric Mayo Peterson, Salt Lake City, UT (US); Michael Andrew Krupka, San Diego, CA (US); and Eric Nathan Ervin, Salt Lake City, UT (US)
Assigned to ELECTRONIC BIOSCIENCES, INC., San Diego, CA (US)
Filed by ELECTRONIC BIOSCIENCES, INC., San Diego, CA (US)
Filed on May 27, 2021, as Appl. No. 17/332,772.
Claims priority of provisional application 63/031,456, filed on May 28, 2020.
Prior Publication US 2021/0370294 A1, Dec. 2, 2021
Int. Cl. B01L 3/00 (2006.01); B82Y 35/00 (2011.01)
CPC B01L 3/502715 (2013.01) [B01L 2200/0689 (2013.01); B01L 2400/0415 (2013.01); B01L 2400/043 (2013.01); B82Y 35/00 (2013.01)] 21 Claims
OG exemplary drawing
 
1. A device, comprising:
a chip comprising two adjacent wells separated by a distance, each of the wells comprising an opening aperture, a bottom and an electrode disposed at the bottom;
a separate seal over the opening aperture of each of the wells;
a nanopore reader in each seal, wherein each reader independently is tethered to one or more magnetic particles;
a first component configured to apply a magnetic field across the wells to magnetically position each reader in each separate seal in each of the two adjacent wells at a distance of about 10 nanometers to 5 micrometers from one other; and
a second component configured to detect an interaction between each reader and a molecule that can be introduced to the device and contacted by a reader.