US 12,138,427 B2
Time averaged basal rate optimizer
Thomas A. Peyser, Menlo Park, CA (US)
Assigned to Dexcom, Inc., San Diego, CA (US)
Filed by DexCom, Inc., San Diego, CA (US)
Filed on May 2, 2024, as Appl. No. 18/653,050.
Application 18/653,050 is a continuation of application No. 18/433,530, filed on Feb. 6, 2024.
Application 18/433,530 is a continuation of application No. 18/367,164, filed on Sep. 12, 2023, granted, now 11,957,877, issued on Apr. 16, 2024.
Application 18/367,164 is a continuation of application No. 17/039,751, filed on Sep. 30, 2020, granted, now 11,813,433, issued on Nov. 14, 2023.
Application 17/039,751 is a continuation of application No. 16/144,782, filed on Sep. 27, 2018, granted, now 10,821,229, issued on Nov. 3, 2020.
Application 16/144,782 is a continuation of application No. 14/307,219, filed on Jun. 17, 2014, granted, now 10,112,011, issued on Oct. 30, 2018.
Claims priority of provisional application 61/856,537, filed on Jul. 19, 2013.
Prior Publication US 2024/0277935 A1, Aug. 22, 2024
Int. Cl. A61M 5/172 (2006.01); A61B 5/145 (2006.01); G16H 20/17 (2018.01); G16H 40/67 (2018.01); G16Z 99/00 (2019.01)
CPC A61M 5/1723 (2013.01) [A61B 5/14532 (2013.01); G16H 20/17 (2018.01); G16H 40/67 (2018.01); G16Z 99/00 (2019.02); A61M 2005/1726 (2013.01); A61M 2202/0007 (2013.01); A61M 2202/07 (2013.01); A61M 2205/3303 (2013.01); A61M 2205/3306 (2013.01); A61M 2205/3313 (2013.01); A61M 2205/3584 (2013.01); A61M 2205/3592 (2013.01); A61M 2205/50 (2013.01)] 30 Claims
OG exemplary drawing
 
1. A method for optimizing a basal rate profile for use with continuous insulin therapy, comprising:
providing a determined basal rate profile from a control algorithm for insulin therapy, wherein the determined basal rate profile comprises an insulin delivery schedule that includes one or more blocks of time, wherein each of the one or more blocks of time defines a basal insulin delivery rate, and wherein each basal insulin delivery rate is determined from the control algorithm;
periodically or intermittently updating the determined basal rate profile based on a retrospective analysis of continuous glucose sensor data, insulin delivery data, or both, over a moving window of time that precedes the periodic or intermittent update of the determined basal rate profile, wherein the moving window of time comprises:
a first time window preceding a first periodic or intermittent update, and
a second time window preceding a second periodic or intermittent update,
wherein the second time window ends later than the first time window; and
dynamically adjusting a basal insulin delivery rate of the determined basal rate profile in response to continuous glucose sensor data,
wherein dynamically adjusting the basal insulin delivery rate comprises incrementally increasing or decreasing basal insulin delivery in response to real time continuous glucose sensor data indicating impending hyperglycemia or impending hypoglycemia.