US 12,138,344 B2
Therapeutic pH responsive compositions
Tian Zhao, Allen, TX (US); Gaurav Bharadwaj, Dallas, TX (US); Xinliang Ding, Grapevine, TX (US); Stephen Gutowski, Irving, TX (US); Jason Miller, Dallas, TX (US); Drew Robinson, Waco, TX (US); Ashley Campbell, Keller, TX (US); and Qingtai Su, Allen, TX (US)
Assigned to OncoNano Medicine, Inc., Southlake, TX (US)
Filed by OncoNano Medicine, Inc., Southlake, TX (US)
Filed on Nov. 3, 2021, as Appl. No. 17/453,468.
Claims priority of provisional application 63/109,220, filed on Nov. 3, 2020.
Prior Publication US 2023/0026946 A1, Jan. 26, 2023
Int. Cl. A61K 47/34 (2017.01); A61K 9/107 (2006.01); A61K 49/00 (2006.01)
CPC A61K 9/107 (2013.01) [A61K 47/34 (2013.01); A61K 49/0056 (2013.01)] 18 Claims
 
1. A micelle comprising:
(i) a block copolymer of Formula (III), or a pharmaceutically acceptable salt, solvate, or hydrate thereof:

OG Complex Work Unit Chemistry
wherein:
n3 is an integer from 10-200;
x3 is an integer from 40-300;
y3 is an integer from 1-6;
z3 is an integer from 1-10;
X3 is a halogen, —OH, or —C(O)OH;
R8 and R9 are each independently an optionally substituted C1-C6 alkyl, C3-C10 cycloalkyl or aryl;
or R8 and R9 are taken together with the corresponding nitrogen to which they are attached to form an optionally substituted 5 to 7-membered ring; and
R10 is indocyanine green; and
(ii) a therapeutic agent encapsulated by the block copolymer,
wherein the therapeutic agent is a protein conjugated to the indocyanine green.