US 12,138,311 B2
Topical tetracycline compositions
Dov Tamarkin, Maccabim (IL); Elana Gazal, Rehovot (IL); Irakliy Papiashvili, Ashkelon (IL); Yohan Hazot, Rehovot (IL); David Schuz, Gimzu (IL); and Rita Keynan, Rehovot (IL)
Assigned to Journey Medical Corporation, Scottsdale, AZ (US)
Filed by Journey Medical Corporation, Scottsdale, AZ (US)
Filed on Feb. 28, 2020, as Appl. No. 16/805,201.
Application 16/805,201 is a continuation of application No. 16/578,252, filed on Sep. 20, 2019, granted, now 10,610,599.
Application 16/578,252 is a continuation of application No. 16/387,407, filed on Apr. 17, 2019, granted, now 10,463,742, issued on Nov. 5, 2019.
Application 16/387,407 is a continuation of application No. 16/235,964, filed on Dec. 28, 2018, granted, now 10,322,186, issued on Jun. 18, 2019.
Application 16/235,964 is a continuation of application No. 15/591,733, filed on May 10, 2017, granted, now 10,213,512, issued on Feb. 26, 2019.
Application 15/591,733 is a continuation of application No. 14/595,882, filed on Jan. 13, 2015, granted, now 9,675,700, issued on Jun. 13, 2017.
Application 14/595,882 is a continuation of application No. 14/469,792, filed on Aug. 27, 2014, granted, now 8,992,896, issued on Mar. 31, 2015.
Application 14/469,792 is a continuation of application No. 14/327,040, filed on Jul. 9, 2014, granted, now 8,865,139, issued on Oct. 21, 2014.
Application 14/327,040 is a continuation of application No. 13/499,475, granted, now 8,871,184, issued on Oct. 28, 2014, previously published as PCT/IB2010/002617, filed on Oct. 1, 2010.
Claims priority of provisional application 61/388,884, filed on Oct. 1, 2010.
Claims priority of provisional application 61/385,385, filed on Sep. 22, 2010.
Claims priority of provisional application 61/380,568, filed on Sep. 7, 2010.
Claims priority of provisional application 61/349,911, filed on May 31, 2010.
Claims priority of provisional application 61/331,126, filed on May 4, 2010.
Claims priority of provisional application 61/322,148, filed on Apr. 8, 2010.
Claims priority of provisional application 61/248,144, filed on Oct. 2, 2009.
Prior Publication US 2020/0261586 A1, Aug. 20, 2020
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 47/44 (2017.01); A61K 8/31 (2006.01); A61K 8/34 (2006.01); A61K 8/36 (2006.01); A61K 9/00 (2006.01); A61K 9/12 (2006.01); A61K 31/137 (2006.01); A61K 31/192 (2006.01); A61K 31/4164 (2006.01); A61K 31/57 (2006.01); A61K 31/573 (2006.01); A61K 31/593 (2006.01); A61K 31/65 (2006.01); A61K 45/06 (2006.01); A61K 47/02 (2006.01); A61K 47/06 (2006.01); A61K 47/10 (2017.01); A61K 47/12 (2006.01); A61K 47/24 (2006.01); A61Q 17/04 (2006.01); A61Q 19/00 (2006.01); A61Q 19/10 (2006.01)
CPC A61K 47/44 (2013.01) [A61K 8/31 (2013.01); A61K 8/342 (2013.01); A61K 8/361 (2013.01); A61K 9/0014 (2013.01); A61K 9/0048 (2013.01); A61K 9/12 (2013.01); A61K 9/122 (2013.01); A61K 9/124 (2013.01); A61K 31/137 (2013.01); A61K 31/192 (2013.01); A61K 31/4164 (2013.01); A61K 31/57 (2013.01); A61K 31/573 (2013.01); A61K 31/593 (2013.01); A61K 31/65 (2013.01); A61K 45/06 (2013.01); A61K 47/02 (2013.01); A61K 47/06 (2013.01); A61K 47/10 (2013.01); A61K 47/12 (2013.01); A61K 47/24 (2013.01); A61Q 17/04 (2013.01); A61Q 19/00 (2013.01); A61Q 19/10 (2013.01); A61K 2800/31 (2013.01); A61K 2800/33 (2013.01)] 23 Claims
 
1. A method of treating rosacea, comprising administering a foamable composition comprising a carrier and a liquefied or compressed gas propellant, the carrier comprising:
a) a tetracycline antibiotic;
b) at least one hydrophobic oil; and
c) an agent comprising (i) at least one fatty alcohol and at least one wax; (ii) at least one fatty acid and at least one wax; (iii) at least one fatty alcohol, at least one fatty acid, and at least one wax; (iv) a wax comprising a hydrogenated oil; or
(v) a combination of two or more waxes;
wherein the carrier does not comprise a surfactant;
wherein the composition has an Aw value of about 0.9 or less; and
wherein upon release from an aerosol container the composition forms a foam.