	US 12,138,310 B2
	Processing method for biopolymers using solvent combinations
Richard Dolph Andersen, Berlin (DE); Annette Assogba-Zandt, Berlin (DE); Elena Maltseva, Schöneiche (DE); and Andreas Voigt, Berlin (DE)
Assigned to SolyPlus GmbH, Haselund (DE)
Appl. No. 16/753,482
Filed by SolyPlus GmbH, Haselund (DE)
PCT Filed Oct. 9, 2018, PCT No. PCT/IB2018/057790 § 371(c)(1), (2) Date Apr. 3, 2020, PCT Pub. No. WO2019/073363, PCT Pub. Date Apr. 18, 2019.
Claims priority of application No. 102017009801.8 (DE), filed on Oct. 12, 2017.
Prior Publication US 2020/0254102 A1, Aug. 13, 2020
Int. Cl. A61K 47/36 (2006.01); A61K 9/14 (2006.01)

CPC A61K 47/36 (2013.01) [A61K 9/146 (2013.01)]

11 Claims

1. A method of processing a biopolymer, comprising:

providing the biopolymer in dry particulate form, wherein the biopolymer is hyaluronic acid or a hyaluronate salt;

optionally providing at least one active pharmaceutical ingredient;

providing a single-phase solvent solution consisting of 30%-40% water and 60%-70% isopropanol or ethanol;

combining the biopolymer in dry particulate form with the single-phase solvent solution, and optionally the at least one active pharmaceutical ingredient; and

mixing the combined mixture by mechanical means to produce a biopolymer matrix having a homogenous swelling.