	US 12,138,300 B2
	Methods and compositions for inducing neural plasticity
Jerry Silver, Bay Village, OH (US); Yu Luo, Shaker Heights, OH (US); and Fucheng Luo, Cleveland Heights, OH (US)
Assigned to CASE WESTERN RESERVE UNIVERSITY, Cleveland, OH (US)
Appl. No. 17/272,393
Filed by CASE WESTERN RESERVE UNIVERSITY, Cleveland, OH (US)
PCT Filed Aug. 29, 2019, PCT No. PCT/US2019/048698 § 371(c)(1), (2) Date Mar. 1, 2021, PCT Pub. No. WO2020/051051, PCT Pub. Date Mar. 12, 2020.
Claims priority of provisional application 62/727,420, filed on Sep. 5, 2018.
Prior Publication US 2021/0330757 A1, Oct. 28, 2021
Int. Cl. A61K 38/46 (2006.01); A61K 9/00 (2006.01); A61P 9/10 (2006.01); A61P 25/28 (2006.01)

CPC A61K 38/465 (2013.01) [A61K 9/0019 (2013.01); A61P 9/10 (2018.01); A61P 25/28 (2018.01); C12Y 301/03048 (2013.01)]

27 Claims

1. A method of promoting compensatory plasticity of spared neural cells of a subject's brain after a neural injury, comprising:

systemically administering to the subject after the neural injury an effective amount of a therapeutic agent comprising a therapeutic peptide and a transport moiety linked to the therapeutic peptide that facilitates uptake of the therapeutic peptide by a cell, wherein the therapeutic peptide comprises an amino acid sequence with at least 70% identity to SEQ ID NO: 32,

wherein the neural injury is caused by cerebral focal ischemia, cerebral global ischemia, acute ischemic stroke, malignant stroke, chronic stroke disease, thrombus, or embolism, and the therapeutic peptide induces compensatory neurite outgrowth in the spared neural cells.