	US 12,138,289 B2
	Extraction and purification of cannabinoids
Zachary White, Dayton, WA (US)
Assigned to M-For, LLC, Oklahoma City, OK (US)
Filed by M-For, LLC, Oklahoma City, OK (US)
Filed on Jul. 13, 2023, as Appl. No. 18/351,940.
Application 18/351,940 is a continuation of application No. 17/554,850, filed on Dec. 17, 2021, granted, now 11,766,466.
Claims priority of provisional application 63/130,012, filed on Dec. 23, 2020.
Prior Publication US 2023/0355697 A1, Nov. 9, 2023
Int. Cl. A61K 36/185 (2006.01); A61K 31/05 (2006.01)

CPC A61K 36/185 (2013.01) [A61K 31/05 (2013.01); A61K 2236/31 (2013.01); A61K 2236/333 (2013.01); A61K 2236/53 (2013.01)]

13 Claims

1. A method for purifying cannabigerol from cannabis, the method comprising:

a. contacting cannabis with an aqueous alkaline solution of a strong inorganic base selected from the group consisting of NaOH, KOH, NH₄OH, and combinations thereof, to extract cannabigerolic acid from the cannabis and produce an aqueous alkaline extract of cannabis, wherein no organic solvents are used;

b. purging the aqueous alkaline extract of cannabis with an inert gas selected from the group consisting of nitrogen, argon, helium, and combinations thereof to produce a purged aqueous alkaline extract of cannabis;

c. removing non-soluble material from the purged aqueous alkaline extract of cannabis via extraction or centrifugation to produce a clarified extract of cannabis;

d. decarboxylating the clarified extract of cannabis at a temperature sufficient to convert the cannabigerolic acid to cannabigerol;

e. crystallizing and precipitating the cannabigerol from the clarified extract at a pH greater than 7 to produce crystallized and precipitated cannabigerol;

f. filtering the crystallized and precipitated cannabigerol to produce 85% to 100% cannabigerol and a barren aqueous solution of the strong inorganic base; and

g. recycling and reusing the barren aqueous solution of the strong inorganic base from step (f) and then extracting new cannabis with the barren aqueous solution of a strong inorganic base selected from the group consisting of NaOH, KOH, NH₄OH, and combinations thereof.