US 12,138,140 B2
Wound covering for wound monitoring and therapeutic agent delivery
Mohsen Akbari, Victoria (CA); Bahram Mirani, Victoria (CA); Aziz Ghahary, Vancouver (CA); and Mohammad A. Siddiqui, Victoria (CA)
Assigned to UVIC INDUSTRY PARTNERSHIPS INC, Victoria (CA)
Appl. No. 16/614,328
Filed by UVic Industry Partnerships Inc., Victoria (CA)
PCT Filed May 17, 2018, PCT No. PCT/IB2018/053491
§ 371(c)(1), (2) Date Nov. 15, 2019,
PCT Pub. No. WO2018/211458, PCT Pub. Date Nov. 22, 2018.
Claims priority of provisional application 62/507,699, filed on May 17, 2017.
Prior Publication US 2020/0188180 A1, Jun. 18, 2020
Int. Cl. A61F 13/00 (2024.01); A61B 5/00 (2006.01); A61B 5/145 (2006.01); A61F 13/01 (2024.01); A61F 13/0203 (2024.01); A61F 13/0206 (2024.01); A61M 35/00 (2006.01); B29C 70/84 (2006.01); B29K 105/00 (2006.01); B29L 31/00 (2006.01); B33Y 10/00 (2015.01); B33Y 80/00 (2015.01)
CPC A61F 13/00063 (2013.01) [A61B 5/14507 (2013.01); A61B 5/14532 (2013.01); A61B 5/14539 (2013.01); A61B 5/14546 (2013.01); A61B 5/6802 (2013.01); A61F 13/00055 (2013.01); A61F 13/01017 (2024.01); A61F 13/01029 (2024.01); A61F 13/01038 (2024.01); A61F 13/0206 (2013.01); A61F 13/0213 (2013.01); A61M 35/30 (2019.05); A61B 5/0022 (2013.01); A61B 5/0077 (2013.01); A61F 2013/00089 (2013.01); A61F 2013/00195 (2013.01); A61F 2013/00285 (2013.01); A61F 13/00995 (2013.01); A61M 2202/0208 (2013.01); A61M 2205/0227 (2013.01); A61M 2205/33 (2013.01); A61M 2205/3327 (2013.01); B29C 70/84 (2013.01); B29K 2005/00 (2013.01); B29K 2105/0061 (2013.01); B29L 2031/753 (2013.01); B33Y 10/00 (2014.12); B33Y 80/00 (2014.12)] 17 Claims
OG exemplary drawing
 
1. A wound covering, comprising:
a flexible main body;
a sensor element incorporated into the main body, the sensor element comprising a mesh formed from a plurality of fibers, the sensor element being configured to undergo a detectable change in appearance in response to a change in a parameter associated with wound exudate, wherein the fibers comprise a plurality of sensor particles and a hydrogel, the sensor particles comprising
one or more indicator compounds configured to undergo the detectable change in appearance in response to the change in the parameter associated with the wound exudate, and
beads comprising an ion-exchange resin or a hydrogel; and
a supply of therapeutic agent configured to diffuse the therapeutic agent from the wound covering into a wound when the wound covering is placed on the wound.
 
9. A wound covering, comprising:
a flexible main body including at least
a first layer comprising a hydrogel; and
a second layer disposed on the first layer, the second layer comprising a porous hydrophobic material;
a sensor element incorporated into the main body and at least partially incorporated into the first layer, the sensor element comprising a mesh formed from a plurality of fibers, the sensor element being configured to undergo a change in appearance in response to a change in a parameter associated with wound exudate; and
a supply of therapeutic agent configured to diffuse the therapeutic agent from the wound covering into a wound when the wound covering is placed on the wound.
 
12. A wound covering, comprising:
a flexible main body;
a sensor element incorporated into the main body, the sensor element comprising a mesh formed from a plurality of fibers, the sensor element being configured to undergo a change in appearance in response to a change in a parameter associated with wound exudate;
a supply of therapeutic agent configured to diffuse the therapeutic agent from the wound covering into a wound when the wound covering is placed on the wound; and
a therapeutic agent delivery element including a mesh formed from a plurality of fibers, the plurality of fibers of the mesh of the therapeutic agent delivery element comprising a hydrogel, wherein
the therapeutic agent is incorporated into the hydrogel.
 
13. A wound covering, comprising:
a flexible main body;
a sensor element incorporated into the main body, the sensor element comprising a mesh formed from a plurality of fibers, the sensor element being configured to undergo a change in appearance in response to a change in a parameter associated with wound exudate;
a supply of therapeutic agent configured to diffuse the therapeutic agent from the wound covering into a wound when the wound covering is placed on the wound; and
a therapeutic agent delivery element including a mesh formed from a plurality of fibers, the plurality of fibers of the mesh of the therapeutic agent delivery element comprising a plurality of porous hydrogel particles, the porous hydrogel particles comprising the therapeutic agent, and
the porous hydrogel particles are configured to release the therapeutic agent when the parameter exceeds a predetermined threshold.
 
16. A wound covering, comprising:
a flexible main body;
a sensor element incorporated into the main body, the sensor element comprising a mesh formed from a plurality of fibers, the sensor element being configured to undergo a change in appearance in response to a change in a parameter associated with wound exudate;
a supply of therapeutic agent configured to diffuse the therapeutic agent from the wound covering into a wound when the wound covering is placed on the wound; and
a humidity sensor element incorporated into the main body, the humidity sensor element comprising a substrate having a coating configured to undergo a change in appearance in response to a change in humidity.