US 12,138,066 B2
Method and system for delivering sensory simulation based on evoked response quantification
Tsvetomira Kirova Tsoneva, Eindhoven (NL); Gary Nelson Garcia Molina, Madison, WI (US); Stefan Pfundtner, Eindhoven (NL); and Sander Theodoor Pastoor, Vleuten (NL)
Assigned to KONINKLIJKE PHILIPS N.V., Eindhoven (NL)
Filed by KONINKLIJKE PHILIPS N.V., Eindhoven (NL)
Filed on Mar. 27, 2020, as Appl. No. 16/832,881.
Claims priority of provisional application 62/826,135, filed on Mar. 29, 2019.
Prior Publication US 2020/0305753 A1, Oct. 1, 2020
Int. Cl. A61B 5/377 (2021.01); A61B 5/00 (2006.01); A61B 5/378 (2021.01); A61B 5/38 (2021.01); A61B 5/381 (2021.01)
CPC A61B 5/377 (2021.01) [A61B 5/378 (2021.01); A61B 5/38 (2021.01); A61B 5/381 (2021.01); A61B 5/4812 (2013.01)] 9 Claims
OG exemplary drawing
 
1. A system for delivering modulated sensory stimulation having varying stimulation intensity levels to a patient, comprising:
a sensor configured to measure brain activity information of a-the patient during a sleep session;
a sensory stimulator configured to deliver sensory stimulation to the patient during the sleep session, the sensory stimulation being modulated sensory stimulation having varying stimulation intensity levels; and
a computer system that comprises one or more physical processors operatively connected with the sensor and the sensory stimulator, the one or more physical processors being programmed with computer program instructions which, when executed cause the computer system to:
determine sleep stage information of the patient based on the brain activity information of the patient during the sleep session;
cause the sensory stimulator to deliver the modulated sensory stimulation to the patient during the sleep session based on the determined sleep stage information of the patient;
obtain stimulation response information from the patient during the sleep session, the stimulation response information including patient brain response to the delivered modulated sensory stimulation; and
determine during the sleep session and based on the stimulation response information a minimum stimulation intensity level and a maximum stimulation intensity level, the minimum stimulation intensity level being a lowest level at which the delivered modulated sensory stimulation elicited a detectable patient brain response to the delivered modulated sensory stimulation and the maximum stimulation intensity level being a saturation level greater than the minimum intensity level at which the brain response of the patient brain response to the delivered modulated sensory stimulation has reached saturation, wherein the saturation level is an intensity level of the delivered modulated stimulation below which the patient brain response to the delivered modulated sensory stimulation changes and above which the patient brain response to the delivered modulated sensory stimulation does not change, and wherein the saturation level is below an intensity level that produces arousals in the patient.