US 12,138,064 B2
Systems, devices and methods using phase-amplitude coupling measures in implantable medical devices
Sharanya Arcot Desai, Sunnyvale, CA (US); Thomas K. Tcheng, Pleasant Hill, CA (US); and Stephen T. Archer, Sunnyvale, CA (US)
Assigned to NeuroPace, Inc., Mountain View, CA (US)
Filed by NeuroPace, Inc., Mountain View, CA (US)
Filed on Mar. 3, 2021, as Appl. No. 17/191,175.
Application 17/191,175 is a division of application No. 15/838,383, filed on Dec. 12, 2017, granted, now 10,966,625.
Prior Publication US 2021/0186407 A1, Jun. 24, 2021
Int. Cl. A61N 1/372 (2006.01); A61B 5/00 (2006.01); A61B 5/291 (2021.01); A61B 5/316 (2021.01); A61B 5/374 (2021.01); A61M 5/172 (2006.01); A61N 1/36 (2006.01); A61N 1/05 (2006.01)
CPC A61B 5/374 (2021.01) [A61B 5/291 (2021.01); A61B 5/316 (2021.01); A61B 5/4094 (2013.01); A61B 5/686 (2013.01); A61B 5/6868 (2013.01); A61M 5/1723 (2013.01); A61N 1/36139 (2013.01); A61N 1/36171 (2013.01); A61N 1/37229 (2013.01); A61M 2210/0693 (2013.01); A61M 2230/10 (2013.01); A61N 1/0534 (2013.01); A61N 1/36064 (2013.01); A61N 1/36067 (2013.01)] 4 Claims
OG exemplary drawing
 
1. An implantable medical device comprising:
at least one sensor configured to be implanted in or on a brain of a patient, and to sense electrical activity of the brain; and
a processor coupled to the at least one sensor and configured to:
derive a phase-amplitude coupling index based on one or more measures of phase-amplitude coupling computed based on the sensed electrical activity;
evaluate the phase-amplitude coupling index relative to phase-amplitude coupling index criterion to determine if the patient is, or may soon be, in a state of abnormal neural activity; and
deliver a neuromodulation therapy to the patient if the patient is determined to be in a state of abnormal neural activity, by being further configured to:
stimulate a first area of the brain with a first stimulation waveform, where the first stimulation waveform comprises electrical stimulation pulses delivered at a low frequency within a low frequency range, and the processor stimulates the first area of the brain with the first stimulation waveform by being further configured to:
apply the sensed electrical activity of the brain to a low frequency range bandpass filter to obtain a low-frequency filtered brain signal, and
deliver the electrical stimulation pulses of the first stimulation waveform to the first area of the brain in synchrony or near-synchrony with fiducial points of the low-frequency filtered brain signal, and
stimulate a second area of the brain with a second stimulation waveform, where the second stimulation waveform comprises electrical stimulation pulses delivered at a high frequency greater than the low frequency, and the processor stimulates the second area of the brain with the second stimulation waveform by being further configured to:
apply the sensed electrical activity to a high frequency range bandpass filter to obtain a high-frequency filtered brain signal, and
deliver the electrical stimulation pulses of the second stimulation waveform to the second area of the brain in synchrony or near-synchrony with fiducial points of the high-frequency filtered brain signal.