US 12,138,016 B2
Method to quantify the hemodynamic and vascular properties in vivo from arterial waveform measurements
Grant Hocking, Alpharetta, GA (US)
Filed by Grant Hocking, Alpharetta, GA (US)
Filed on Jun. 9, 2021, as Appl. No. 17/343,067.
Claims priority of provisional application 63/039,524, filed on Jun. 16, 2020.
Prior Publication US 2021/0386299 A1, Dec. 16, 2021
Int. Cl. A61B 5/1455 (2006.01); A61B 5/00 (2006.01); A61B 5/02 (2006.01); A61B 5/021 (2006.01); A61B 5/0265 (2006.01); A61B 5/0285 (2006.01); A61B 5/029 (2006.01); A61B 8/06 (2006.01)
CPC A61B 5/02007 (2013.01) [A61B 5/02035 (2013.01); A61B 5/02116 (2013.01); A61B 5/0265 (2013.01); A61B 5/0285 (2013.01); A61B 5/029 (2013.01); A61B 5/14552 (2013.01); A61B 5/4839 (2013.01); A61B 5/6843 (2013.01); A61B 5/7278 (2013.01); A61B 8/06 (2013.01)] 31 Claims
OG exemplary drawing
 
1. A method of quantifying hemodynamic parameters and mechanical anelastic in vivo properties of an arterial blood vessel of a subject in near real time, the method comprising the steps of:
a. obtaining a pulse arterial pressure waveform (PPW), a pulse arterial volume waveform (PVW) and a pulse arterial velocity waveform (PUW) from the arterial blood vessel in the subject over a cardiac cycle;
b. calculating a time phase shift between the PPW and the PVW, blood pressure, and power law components of an anelastic model from the waveform PPW, waveform PVW, blood viscosity, cardiac output, performance of heart valves from the waveform PPW and waveform PUW; and
c. determining the mechanical anelastic in vivo properties of the arterial blood vessel, blood pressure, stroke volume, cardiac output, blood viscosity, performance of aorta and mitral heart valves, and vascular tone of the subject based upon the calculations.