US 12,137,683 B2
Systems and methods for ex-vivo organ care
Waleed H. Hassanein, North Andover, MA (US); Richard Bringham, North Andover, MA (US); Giovanni Cecere, Needham, MA (US); Tamer I. Khayal, North Andover, MA (US); Ronald Taylor, Jr., Chester, NH (US); and Hossam Algamil, Scranton, PA (US)
Assigned to TRANSMEDICS, INC., Andover, MA (US)
Filed by TransMedics, Inc., Andover, MA (US)
Filed on May 2, 2023, as Appl. No. 18/310,832.
Application 14/939,845 is a division of application No. 11/245,957, filed on Oct. 7, 2005, granted, now 9,215,867, issued on Dec. 22, 2015.
Application 18/310,832 is a continuation of application No. 17/530,037, filed on Nov. 18, 2021, granted, now 11,723,357.
Application 17/530,037 is a continuation of application No. 16/396,059, filed on Apr. 26, 2019, granted, now 11,191,263.
Application 16/396,059 is a continuation of application No. 14/939,845, filed on Nov. 12, 2015, granted, now 10,314,303, issued on Jun. 11, 2019.
Claims priority of provisional application 60/725,168, filed on Oct. 6, 2005.
Claims priority of provisional application 60/694,971, filed on Jun. 28, 2005.
Claims priority of provisional application 60/616,835, filed on Oct. 7, 2004.
Prior Publication US 2023/0263156 A1, Aug. 24, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A01N 1/02 (2006.01)
CPC A01N 1/0242 (2013.01) [A01N 1/02 (2013.01); A01N 1/0226 (2013.01); A01N 1/0247 (2013.01)] 30 Claims
OG exemplary drawing
 
1. A method comprising:
placing an ex-vivo heart in a chamber of an organ care system;
connecting the ex-vivo heart to a perfusion fluid circuit of the organ care system;
starting a pump configured to provide, via the perfusion fluid circuit, a perfusion fluid to the ex-vivo heart;
synchronizing at least one maximum output of the pump with an r-wave of the ex vivo heart;
testing the ex-vivo heart or the organ care system;
adjusting a setting of the organ care system in response to a result of the testing; and
after adjusting the setting of the organ care system in response to the result of the testing, re-testing the ex-vivo heart or the organ care system.