US 12,469,610 B2
Systems and methods for treating blood clots with nerve stimulation
Joseph P. Errico, Palm Beach Gardens, FL (US); Bruce J. Simon, Santa Fe, NM (US); Peter Staats, Atlantic Beach, FL (US); and Thomas Errico, Coral Gables, FL (US)
Assigned to ElectroCore, Inc., Rockaway, NJ (US)
Filed by ELECTROCORE, INC, Rockaway, NJ (US)
Filed on Sep. 13, 2022, as Appl. No. 17/944,131.
Application 17/944,131 is a division of application No. 17/471,962, filed on Sep. 10, 2021, granted, now 11,894,148.
Application 17/471,962 is a continuation in part of application No. 16/838,953, filed on Apr. 2, 2020.
Application 16/838,953 is a continuation in part of application No. 16/229,299, filed on Dec. 21, 2018, granted, now 11,581,090.
Claims priority of provisional application 62/609,807, filed on Dec. 22, 2017.
Prior Publication US 2023/0005626 A1, Jan. 5, 2023
Int. Cl. A61N 1/32 (2006.01); A61N 1/36 (2006.01); G16B 35/00 (2019.01); G16H 50/80 (2018.01); G16H 70/60 (2018.01)
CPC G16H 50/80 (2018.01) [A61N 1/36 (2013.01); A61N 1/36034 (2017.08); A61N 1/36053 (2013.01); G16B 35/00 (2019.02); G16H 70/60 (2018.01)] 14 Claims
OG exemplary drawing
 
1. A method for treating blood clots in a patient, the method comprising:
positioning a contact surface of a device in contact with an outer skin surface of a neck of the patient;
applying, via the device, when the contact surface is in contact with the outer skin surface of the patient, an electrical impulse transcutaneously, via the contact surface, through the outer skin surface of the patient to a cervical branch of the vagus nerve of the patient;
wherein the electrical impulse has a frequency of about 1 kHz to about 20 kHz and is sufficient to reduce a number of autoantibodies associated with blood clotting, to reduce a level of blood clotting in the patient; and
applying the electrical impulse to the patient according to a treatment paradigm, wherein the treatment regimen consists of applying the electrical impulse to the patient as a first single dose for a time period of about 90 seconds to about 2 minutes and a second single dose for a time period of about 90 seconds to about 2 minutes, wherein the second single dose is applied five minutes or less after the first single dose and, wherein the first and second doses are each applied about 2 to about 12 times per day.