US 12,468,872 B2
Low volume filling of a liquid into a container
Imke Sonja Ludwig, Basel (CH); Joerg Luemkemann, Basel (CH); Julien Boeuf, Mannheim (DE); and Tim Dreckmann, Basel (CH)
Assigned to HOFFMANN-LA ROCHE INC., Little Falls, NJ (US)
Appl. No. 17/616,035
Filed by HOFFMANN-LA ROCHE INC., Little Falls, NJ (US)
PCT Filed Jun. 5, 2020, PCT No. PCT/EP2020/065584
§ 371(c)(1), (2) Date Dec. 2, 2021,
PCT Pub. No. WO2020/245330, PCT Pub. Date Dec. 10, 2020.
Claims priority of application No. 19179146 (EP), filed on Jun. 7, 2019.
Prior Publication US 2022/0300685 A1, Sep. 22, 2022
Int. Cl. G06F 30/28 (2020.01); G06F 111/10 (2020.01); G06F 113/08 (2020.01); G06F 119/14 (2020.01)
CPC G06F 30/28 (2020.01) [G06F 2111/10 (2020.01); G06F 2113/08 (2020.01); G06F 2119/14 (2020.01)] 15 Claims
OG exemplary drawing
 
1. A process of assembling a filling system for low volume filling of a liquid into a container comprising:
obtaining plural liquid forwarding devices configured to provide the liquid from a reservoir to the container;
simulating operation of each of the liquid forwarding devices by numerically modelling flow patterns of the liquid when being forwarded by the liquid forwarding devices, and by determining a shear stress rate for each of the liquid forwarding devices based on the modelled flow patterns;
determining an appropriateness for each of the liquid forwarding devices by comparing operation parameters of the liquid forwarding of the liquid forwarding devices, wherein the operation parameters include the determined shear stress rates;
selecting, from the plural liquid forwarding devices, a liquid forwarding device having the highest determined appropriateness; and
installing the selected liquid forwarding device into the filling system.