US 12,468,137 B2
Apparatus for homeothermic manipulation of live animal for microscopic imaging of internal tissue
Pilhan Kim, Daejeon (KR); Yoonha Hwang, Daejeon (KR); and Eunjoo Song, Daejeon (KR)
Assigned to KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY, Daejeon (KR); and IVIM Technology, Inc., Daejeon (KR)
Filed by KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY, Daejeon (KR); and IVIM Technology, Inc., Daejeon (KR)
Filed on Aug. 12, 2022, as Appl. No. 17/887,336.
Claims priority of application No. 10-2021-0107411 (KR), filed on Aug. 13, 2021.
Prior Publication US 2023/0052607 A1, Feb. 16, 2023
Int. Cl. A61B 5/01 (2006.01); A61B 5/00 (2006.01); A61F 7/00 (2006.01); A61F 7/08 (2006.01); G02B 21/00 (2006.01); G02B 23/24 (2006.01)
CPC G02B 21/0076 (2013.01) [A61B 5/01 (2013.01); A61B 5/702 (2013.01); A61F 7/007 (2013.01); A61F 7/08 (2013.01); A61B 2503/40 (2013.01); A61B 2503/42 (2013.01); A61B 2562/0271 (2013.01); A61F 2007/0093 (2013.01); G02B 23/243 (2013.01)] 7 Claims
OG exemplary drawing
 
1. A fixation and body temperature maintaining apparatus for fixing a small animal in order to generate a high-resolution micro image of a predetermined tissue of the small animal within a biomicroscope with an object lens, comprising:
a plate heater with a heat wire installed therein, on which the small animal is enabled to be directly placed;
a glass heater holder fixed to a hole of the plate heater; and
a glass heater fixed to the glass heater holder, and located above the tissue of the small animal and maintaining flatness of the tissue, and increasing a temperature of the tissue itself,
wherein the glass heater comprises a cover glass serving to adjust a refractive index of the object lens, a glass holder fixing the cover glass, a glass holder cover, and a heat wire heater, and
the glass holder and the heat wire heater are integrally formed, and the glass holder and the glass holder cover are enabled to be separated from each other and fixed by using a screw and a magnet.