US 12,467,932 B2
Methods of improving neurodegenerative disorders by targeted delivery of therapeutic agents
Ali R. Rezai, Morgantown, WV (US); Victor Finomore, Jr., Morgantown, WV (US); Jeff Carpenter, Morgantown, WV (US); and Marc Haut, Morgantown, WV (US)
Assigned to West Virginia University Board of Governors on behalf of West Virginia University, Morgantown, WV (US)
Filed by West Virginia University Board of Governors on behalf of West Virginia University, Morgantown, WV (US)
Filed on Oct. 24, 2023, as Appl. No. 18/383,367.
Claims priority of provisional application 63/435,449, filed on Dec. 27, 2022.
Claims priority of provisional application 63/418,733, filed on Oct. 24, 2022.
Prior Publication US 2024/0173575 A1, May 30, 2024
Int. Cl. G01N 33/00 (2006.01); A61K 9/50 (2006.01); A61N 7/00 (2006.01); A61N 7/02 (2006.01); C07K 16/18 (2006.01); G01N 29/34 (2006.01); G01N 33/53 (2006.01); G01N 33/68 (2006.01)
CPC G01N 33/6896 (2013.01) [A61K 9/50 (2013.01); A61N 7/00 (2013.01); A61N 7/02 (2013.01); C07K 16/18 (2013.01); G01N 29/34 (2013.01); G01N 33/53 (2013.01); A61N 2007/0021 (2013.01); A61N 2007/0026 (2013.01); A61N 2007/0039 (2013.01); G01N 2800/28 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A method of improving a neurodegenerative disorder in a human patient suffering therefrom comprising:
determining a target site of the human patient's brain that is affected by the neurodegenerative disorder; and
providing a therapy to the human patient comprising:
applying a focused ultrasound (FUS) sonication via an ultrasound delivery device to the target site based on at least one feedback parameter comprising at least one or more of an imaging parameter; an acoustic microbubble vibration analysis; an optical parameter; a bodily fluid parameter; or a physiological or anatomical parameter; and
introducing a therapeutic agent to the target site before, during, or after application of the FUS sonication.