	US 12,467,921 B2
	Antibodies and assays for detection of Burkholderia mallei
Lee Lee Teng, Hong Kong (CN); Patrick Chiu Yat Woo, Hong Kong (CN); Elaine Chan, Hong Kong (CN); Susanna Kar Pui Lau, Hong Kong (CN); Man Lung Yeung, Hong Kong (CN); and Ulrich Wernery, Dubai (AE)
Assigned to Versitech Limited, Hong Kong (CN); and Central Veterinary Research Laboratory, Dubai (AE)
Filed by Versitech Limited, Hong Kong (CN); and Central Veterinary Research Laboratory, Dubai (AE)
Filed on Aug. 31, 2021, as Appl. No. 17/463,109.
Prior Publication US 2023/0075982 A1, Mar. 9, 2023
Int. Cl. C07K 16/12 (2006.01); G01N 33/569 (2006.01)

CPC G01N 33/56911 (2013.01) [C07K 16/1203 (2013.01); C07K 2317/24 (2013.01); C07K 2317/565 (2013.01); C07K 2317/567 (2013.01); G01N 2400/50 (2013.01); G01N 2469/20 (2013.01)]

49 Claims

1. An isolated antibody or antigen binding fragment thereof that binds to lipopolysaccharide (LPS) from Burkholderia mallei, Burkholderia pseudomallei, or Burkholderia thailandensis, the isolated antibody comprising:

a heavy chain variable domain (VH) comprising three heavy chain complementarity regions (CDRs), VHCDR1, VHCDR2, and VHCDR3, and

a light chain variable domain (VL) comprising three light chain CDRs, VLCDR1, VLCDR2, and VLCDR3;

wherein the VHCDR1, VHCDR2, and VHCDR3 are VHCDR1, VHCDR2, and VHCDR3, respectively, of monoclonal antibody B5 produced from a hybridoma deposited under ATCC Accession Deposit Number PTA-127021, and

wherein the VLCDR1, VLCDR2, and VLCDR3 are VLCDR1, VLCDR2, and VLCDR3, respectively, of monoclonal antibody B5 produced from the hybridoma deposited under ATCC Accession Deposit Number PTA-127021.