US 12,467,916 B2
Method for estimating arterial blood values
Bruno Graversen, Hadsund (DK); and Bjarne Flou, Hadsund (DK)
Assigned to Roche Diagnostics A/S, Copenhagen V (DK)
Appl. No. 16/770,785
Filed by Roche Diagnostics A/S, Copenhagen V (DK)
PCT Filed Dec. 12, 2018, PCT No. PCT/EP2018/084530
§ 371(c)(1), (2) Date Jun. 8, 2020,
PCT Pub. No. WO2019/115605, PCT Pub. Date Jun. 20, 2019.
Claims priority of application No. 17206647 (EP), filed on Dec. 12, 2017.
Prior Publication US 2021/0164966 A1, Jun. 3, 2021
Int. Cl. G01N 33/49 (2006.01); A61B 5/15 (2006.01); G16H 10/40 (2018.01); G16H 50/30 (2018.01); G16H 50/50 (2018.01)
CPC G01N 33/4925 (2013.01) [G16H 10/40 (2018.01); G16H 50/30 (2018.01); G16H 50/50 (2018.01); A61B 5/15003 (2013.01)] 8 Claims
OG exemplary drawing
 
1. A blood gas analysis system comprising:
a pulse oximeter configured to acquire arterial oxygen saturation information;
an anaerobic venous blood sampling device;
a user interface configured to receive:
an arterial oxygen saturation value that has been acquired from the pulse oximeter; and
a venous acid-base status that has been acquired from the anaerobic venous blood sampling device, the acid-base status comprising at least one of a pH value, a partial pressure of carbon dioxide value and a partial pressure of oxygen value; and
a processor cooperative with a computer readable medium to operate a computer model that predicts a conversion of venous blood values to arterial blood values, wherein the blood gas analysis system is configured such that it does not need to acquire blood gas information from an arterial puncture blood sample in order to perform an arterial blood gas analysis on a patient but instead is configured such that the computer model estimates an arterial oxygenation value and arterial acid-base status through a simulated metabolism and the received venous blood values, such that if the estimated arterial oxygenation value is:
(a) less than a corresponding venous oxygenation value by less than a predefined threshold, the computer model uses a replacement value being a function of the corresponding venous oxygenation value instead of the estimated arterial oxygenation value;
(b) less than the corresponding venous oxygenation value by more than a predefined threshold value, the computer model generates an error message; or
(c) at least as great as the corresponding venous oxygenation value, the computer model retains the estimated arterial oxygenation value;
wherein the blood gas analysis system is further configured to present results of the arterial blood gas analysis through the user interface, the results comprising one of (i) an arterial acid-base status of the patient based on the corresponding venous oxygenation value, (ii) the error message or (iii) an arterial acid-base status of the patient based on the retained estimated arterial oxygenation value.